Fatigue, Multiple Sclerosis
Conditions
Keywords
multiple sclerosis, fatigue
Brief summary
This study is a controlled pilot study with 17 participants with Multiple Sclerosis (MS). The primary goal of this study is to objectively examine the effects of a multimodal dance intervention on walking-related performance fatigability. The secondary aim is to investigate the effects of a multimodal dance intervention on other MS symptoms related to fatigue and fatigability. The following research questions will be addressed: 1. Does a multimodal dance intervention have positive effects on walking-related fatigability? 2. Does a multimodal dance intervention have positive effects on other MS symptoms related to fatigue and fatigability?
Detailed description
This study distinguish two groups contributing to a dance and art production. The experimental group will perform 10 weeks of dance training, while the other group will contribute to the production in various ways (e.g. word art, photography, painting, …). Measures will be taken before and after the training or assistance in the production.
Interventions
OTHERMS-Dance
The experimental group will perform 10 weeks of dance training
OTHERMS-Art
The other group will contribute to the production in various ways (e.g. word art, photography, painting, …)
Sponsors
Hasselt University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
This study distinguish two groups contributing to a dance and art production. The experimental group will perform 10 weeks of dance training, while the other group will contribute to the production in various ways (e.g. word art, photography, painting, …). Measures will be taken before and after the training or assistance in the production.
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age between 18 - 70 years * Confirmed diagnosis according to the McDonald criteria * Able to walk independently or with bilateral support for 6 minutes * Signed the informed consent
Exclusion criteria
* Exacerbation or relapse within last 3 months before onset study * Other medical conditions interfering with walking ability (e.g. cardiac or respiratory diseases, arthritis, fibromyalgia, Parkinson and stroke)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| motor fatigability | Baseline | Performance motor fatigability: Calculating the Distance Walked Index (DWI) during 6MWT. Formula for walking-related performance fatigability: DWI = (\[Distance walked at minute 6 - Distance walked at minute 1\]/Distance walked at minute 1) × 100 |
| Trait motor fatigue | baseline | Modified Fatigue Impact Scale (MFIS) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Coördination test with lower limbs | baseline | seated bipedal coordination task (knee flexion and extension movements during 6 minutes, and metronome based 0,75 Hz, 1Hz and 1,5 Hz for 1 minute) |
| Perceived motor fatigability | Baseline | VAS increase minute per minute during 6MWT (range 0-10) |
| Performance cognitive fatigability and cognitive capacity | Baseline | PASAT and SDMT total score and correct answers last ⅓ vs first ⅓ |
| Trait fatigue | Baseline | Fatigue Severity Scale (FSS) : range 1-7 |
| MSIS-29 Questionnaire | Baseline | Impact of MS via a questionnaire. 29 items, total score on 145. |
| SF-36 Questionnaire | Baseline | Quality of Life health related questionnaire. Scale 0-100 |
| T25FW test | Baseline | patients have to walk 25 feet as fast as possible. Determined in seconds |
| MSWS-12 Questionnaire | Baseline | Questionnaire about walking in MS, 12 items, total score on 60, minimum score 12. |
| 5xSTS T25FW | Baseline | 5 times sit to stand test, where patients have to stand and sit 5 times as fast as possible. Determined in seconds |
| DGI (Dynamic gait index) | Baseline | patient have to perform several static and dynamic balance test. A four-point ordinal scale, ranging from 0-3. 0 indicates the lowest level of function and 3 the highest level of function. Total Score = 24 |
| EmNSA | Baseline | Dynamic gait index: patient have to perform several static and dynamic balance test. A ordinal scale, ranging from 0-2. 0 indicates the lowest level of function and 2 the highest level of function. Total Score = 48 |
| CMI (Cognitive motor interference) | Baseline | Dual task testing during 1 min tasks and 6 minutes task to measure alertness of movement control. Dual task testing during 1 min tasks and 6 minutes task to measure alertness of movement control. |
| ABC scale | Baseline | Activity balance confidence scale. Scale has 16 items and is transferred to a percentage. |
| NHPT (Nine hole peck test) | Baseline | Nine hole peck test: descriptive measure for hand dexterity. Measured in seconds. |
Countries
Belgium
Outcome results
None listed