Chronic Kidney Disease Mineral and Bone Disorder, Dialysis, Secondary Hyperparathyroidism, Vascular Calcification
Conditions
Brief summary
This is a prospective cohort study aimed to evaluate change of cardiovascular calcification after parathyroidectomy in patients with end-stage renal disease on dialysis compared with control group on conservative treatment.
Interventions
None listed
Sponsors
Saint Petersburg State University, Russia
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age \> 18 years 2. ESRD patients receiving long-term hemodialysis or peritoneal dialysis treatment 3. Severe secondary hyperparathyroidism defined as iPTH level \> 800 pg/ml, followed with hypercalcemia and/or hyperphosphatemia; with presence of one or more nodular or diffuse parathyroid hyperplasia confirmed with CT
Exclusion criteria
1\. Primary hyperparathyroidosis as a cause of ESRD
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in coronary artery calcium score measured with CT | 18 months |
| Change in vascular calcification score measured with semi-quantitative (Kauppila) test | 18 months |
Secondary
| Measure | Time frame |
|---|---|
| Change in serum calcium level | 18 months |
| Change in serum phosphate level | 18weeks |
| Change in heart valve calcium score | 18 months |
| Serious adverse events (cardiovascular events, death, fractures, emergency hospital admissions) during the follow-up period | 18 months |
| Change in alkaline phosphatase | 18 months |
| Change in intact parathyroid hormone (iPTH) level | 18 months |
Countries
Russia
Outcome results
None listed