Lung Cancer
Conditions
Brief summary
During one-lung ventilation in patients undergoing thoracic surgery, the persistent flow in the non-ventilated lung increases intrapulmonary shunt and decreases systemic arterial oxygenation. This prospective, randomized, double blind study was conducted to evaluate the effects of inhaled iloprost during one-lung ventilation on arterial oxygenation and shunt fraction during thoracic surgery.
Interventions
DRUGInhaled iloprost
Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.
DRUGDistilled water
Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.
Sponsors
The Catholic University of Korea
Seoul St. Mary's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* elective video-assisted thoracoscopic surgery (VATS) lobectomy * 20 \< age \< 75 * American Society of Anesthesiologists (ASA) classification I\ III
Exclusion criteria
* ASA classification IV * New York Heart Association (NYHA) class III\ IV * Severe obstructive lung disease / restrictive lung disease * Pulmonary hypertension * End-stage organ disease (i.e. hepatic failure, renal failure) * Arrhythmia * Previous history of thoracic surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PaO2(partial pressure of arterial oxygen) | 30 min after treatment | ABGA |
| Pulmonary shunt fraction | 30 min after treatment | Qs/Qt = (CcO2-CaO2) / (CcO2-CvO2) |
Countries
South Korea
Outcome results
None listed