Breast Cancer Female
Conditions
Keywords
Radiotherapy, CETC, CTC, breast cancer
Brief summary
The aim of this study was to investigate the systemic effect of radiotherapy on patients with primary non-metastatic breast cancer using CETC and to analyze possible changes in CETC quantity under adjuvant radiotherapy.
Detailed description
In cooperation with the Women's Hospital of the Friedrich Schiller University in Jena, a total of 161 patients with clinically proven, primarily non-metastatic breast cancer were sampled and examined before and after radiotherapy over a period from 09/2002 to 09/2012. The MAINTRAC method was used to quantitatively determine the amount of CETC in the blood and to observe its peritherapeutic course.
Interventions
RADIATIONradiation
Sponsors
University of Jena
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* histologically confirmed invasive breast carcinoma * age \>= 18 years * exclusive treatment at the Jena University Hospital * complete curative-intended adjuvant or definite radiotherapy * at least 2 blood collections (before the start of therapy, after the end of the RT)
Exclusion criteria
* presence of metastases * recurrence * DCIS, inflammatory breast cancer * second malignancy \<10 years before diagnosis of breast cancer * radiotherapeutic pretreatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival | up to 10 years | from the start of Radiotherapy until death / last seen during follow up |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Disease free survival | up to 10 years | from the start of Radiotherapy until relapse or metastasis / last seen during follow up |
Countries
Germany
Outcome results
None listed