Uncontrolled Donation After Circulatory Determination of Death
Conditions
Keywords
unexpected cardiopulmonary arrest, potential organ donors
Brief summary
World-wide, patients waiting for organ transplantation exceed the number of organs available. Many European countries have a uDCDD program which contribute to 10-15% of the donor pool. In Canada, this type of program does not exist. The purpose of this study is to report how many deceased person fulfill the criteria for uncontrolled DCDD in a Canadian medical center.
Detailed description
While transplantation has become the definitive treatment for many people suffering end-stage organ failure, demand exceeds supply. For many years, donation after neurological death represented the principal source of organs for transplantation. In the last decade, prevention measures, improvements in neurocritical care, and decompressive craniectomy have led to a significant decrease in the number of non-directed donors (NDDs). In such situations, alternative sources for organ donation must be identified. Cardiac-arrest patients could provide a solution to this organ shortage. Patients who have experienced unexpected in or out of hospital cardiopulmonary arrest could become organ donors. Organ donation following uncontrolled cardiocirculatory death is currently practiced in many European countries. However, in Canada, it's not yet authorized. Yet, each deceased could save up to four lives. The purpose of this study is to determine the organ potential for a cohort of patient who had died from a cardiopulmonary arrest at the CHUS in 2015 and assess the effect of the implementation of a uDCD program on the number of additional donors.
Interventions
None listed
Sponsors
Université de Sherbrooke
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* All patients treated for cardiocirculatory arrest at the CIUSSS-Estrie CHUS in 2015.
Exclusion criteria
* Patients with a status of no resuscitation * Pediatric patients (\<18 years old) * Adults \>65 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Potential contribution of a uDCDD program on the number of additional donors. | 1 year | Defined as (must meet all criteria): * Age ≤70 years old * Absence of obvious cause of death (rigor mortis, decapitation, overwhelming traumatic injury) * Absence of surgical cause of cardiac arrest * No sign of IV drug abuse * No history of malignancies |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of the implementation of a uDCDD program on the number of additional organs suitable for transplantation. | 1 year | Effect of the implementation of a uDCDD program on the number of additional organs suitable for transplantation. |
| Number of tissus donors | 1 year | Number of tissus donors |
| Potential obstacles and solutions related to the implementation of a uDCDD program in Canada. | 1 year | Potential obstacles and solutions related to the implementation of a uDCDD program in Canada. |
| Areas of future research. | 1 year | Areas of future research. |
Outcome results
None listed