Heart Failure
Conditions
Brief summary
The study is aimed to evaluate the improvement of the left ventricular volumes and of the left ventricular ejection fraction in a population of ICD patients with heart failure and left ventricle systolic dysfunction undergoing therapy with Sacubitril/Valsartan (according to current Guidelines), during a 6-month follow-up.
Detailed description
Consecutive, unselected patients with heart failure and left ventricle systolic dysfunction, carrying a single-chamber or a bicameral implantable cardioverter defibrillator (ICD) for primary prevention of sudden death, undergoing therapy with Sacubitril/Valsartan (according to current Guidelines) will be enrolled in the study. A two-dimensional echocardiogram with evaluation of left ventricular end-diastolic volume, left ventricular end-systolic volume, and left ventricular ejection fraction will be performed, according to standard clinical practice, at the beginning of the observation, and at a 6-month follow-up. The improvement of the left ventricle volumes and of the left ventricular ejection fraction will be evaluated.
Interventions
DIAGNOSTIC_TESTtwo-dimensional echocardiogram
two-dimensional echocardiogram with evaluation of left ventricle volumes and of left ventricular ejection fraction
Sponsors
Azienda Ospedaliera Cardinale G. Panico
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* heart failure * left ventricular systolic dysfunction * carrying a single-chamber or a bicameral implantable cardioverter defibrillator implanted for primary prevention of sudden death * undergoing therapy with Sacubitril/Valsartan according to current Guidelines
Exclusion criteria
* age \<18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement in left ventricular ejection fraction | at enrollment and at 6 months of follow-up | Difference between the ejection fraction observed at baseline and that observed at 6 months of follow-up |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Reduction in left ventricle volumes | at enrollment and at 6 months of follow-up | Difference between the left ventricle volumes measured at baseline and those measured at 6 months of follow-up |
Countries
Italy
Outcome results
None listed