Childhood Cancer
Conditions
Keywords
exercise, strength training, activities of daily living, childhood cancer, leukemia, Non-Hodgkin lymphoma
Brief summary
Reduced activity levels and reduced muscular strength could severely impair the activities of daily living (ADLs) in pediatric leukemia and Non-Hodgkin lymphoma patients. Increased muscle strength is associated with improved accomplishment of ADLs and consequently greatest possible normality, autonomy and mobility. Primary outcome of this RCT (n=20/20) is the analysis of effects of a treatment-associated and close to every day life strength training (2-3 times/week) compared to a general exercise program (standard care).
Interventions
OTHERExercise
specific strength training
Sponsors
Technical University of Munich
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
4 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed with Acute Leukemia or Non-Hodgkin Lymphoma * Diagnosed and/or treated at the Kinderklinik München Schwabing, Technische Universität München * Informed consent as documented by signature
Exclusion criteria
* Medical contraindications regarding strength training (e.g. risk of bleeding, ...) * Contraindications to one of the inclusion criteria mentioned above * Inability to follow the procedures and understand the intervention and assessments of this study, e.g. due to cognitive impairment, language problems, psychological disorders etc.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of score of the Activities Scale for Kids - performance version | Change of the ASK score from baseline to 3 months, change from 3 months to 6 months, change from 6 months to 12 months | The ASK - Activities Scale for Kids performance version by NL Young assesses an overall summary score (0-100) of self-reported activities of daily living in children and adolescents. The scale monitors changes associated with therapeutic interventions. Higher values represent a better outcome. The ASK contains 30 items in 7 sub-domains (personal care, dressing, other skills, locomotion, play, standing skills and transfer). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of motor performance analyzed with the Motor performance test in Pediatiric Oncology (MOON) | Change of motor performance from baseline to 6 months | Motor performance is assessed by the MOON-test, a tool to examine motor performance abilities in children and adolescents during and after cancer treatment. There's no summary score; reference values of healthy children enable comparison of the tested children. |
| Change of level of physical activity | Change of physical activity level from baseline to 3 months, from 3 to 6 months, from 6 to 12 months | Physical activity is assessed using an accelerometer (movisens) for the period of 7 days. |
| Change in performance in a parkour in activities of daily living | Change of score in the parkour from baseline to 6 months | A standardized parkour with tasks imitating activities of daily living is used to objectively verify the ASK score. Points from 0-4 are counted for each task depending on quality of movement (0 = task can not be completed, 1 = task can be completed with help, 2 = task can be completed with several attempts, 3 = task can be completed with only little effort, 4 = task can be completed without any problems or effort). There are no reference values for the parkour, but intra-individual changes are analyzed. |
Countries
Germany
Outcome results
None listed