Organ Failure, Multiple
Conditions
Brief summary
Hyperthermic intraperitoneal chemotherapy is a major surgery for tumor peritoneal metastasis. For anesthesiologist, the intra-operative fluid control is always a big challenge. We try to compare the prognosis of lactate-directed and goal-directed therapy. We expect to confirm the better prognosis of lactate-directed therapy.
Interventions
OTHERLactate-directed therapy
If the lactate level elevates, we transfuse pRBC to increase Hct\>30%. If Hct \>30%, dopamine infusion starts.
If SVV\>15%, transfuse lactate ringer/normal saline alternatively to keep SVV\<15%.
Sponsors
Taipei Medical University WanFang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients receiving hyperthermic intraperitoneal chemotherapy
Exclusion criteria
* Unable to set arterial line Severe liver or renal disease Severe heart disease Unconscious patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pulmonary complication | 1 week | X-ray findings of airspace or interstitial opacity, lobar consolidation, or pleural effusions; severe respiratory failure requiring respiratory support |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Renal complication | 1 week | oliguria with urine output\<0.5 ml/kg/h for more than 4 h, creatinine increase\>30 % of preoperative values, dialysis |
Outcome results
None listed