Ventilation Therapy; Complications
Conditions
Brief summary
Decrease thickness of diaphragm muscle, cross-sectional area of rectus femoris and biceps brachii muscle, and increase in CRP would affect ventilator length of use in critically ill patients in ICU
Interventions
OTHERDiaphragm thickness
measured at apposition zone using ultrasonography in mm
OTHERCross-sectional area of rectus femoris muscle
measured at lower one-third line between Spina iliaca anterior inferior (SIAI) and upper border femur patella using ultrasonography in cm\^2
OTHERCross-sectional area of biceps brachii
measured at biceps brachii muscle using ultrasonography in cm\^2
DIAGNOSTIC_TESTC-Reactive Protein (CRP) Level
quantitative CRP using ELISA method in mcg/mL
Sponsors
Indonesia University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who had Modified Rankin Score \< 4 in 1 month before admitted into ICU
Exclusion criteria
* Pregnant women * Patients who had intubation more than 24 hours before admitted at ICU Cipto Mangunkusumo Hospital * Patients who had a history or prior to thoracic or heart surgery 14 days before admission * Patients who had severe peripheral muscle dysfunction * Patients who had a history of admission in hospital for more than 2 weeks on the last 3 months * Patients who predicted will be using ventilator for less than 4 days * Patients who suffered acute respiratory distress syndrome (ARDS) with a ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) less than 200 * Patients who declined to participate in this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between changes in diaphragm thickness with ventilator length of use | 30 days from admission | Correlation between changes in diaphragm thickness with ventilator length of use: \< 7 days or \>7 days |
| Correlation between changes in cross-sectional area of rectus femoris muscle with ventilator length of use | 30 days from admission | Correlation between changes in cross-sectional area of rectus femoris muscle with ventilator length of use: \< 7 days or \>7 days |
| Correlation between changes in cross-sectional area of biceps brachii muscle with ventilator length of use | 30 days from admission | Correlation between changes in cross-sectional area of biceps brachii muscle with ventilator length of use: \< 7 days or \>7 days |
| Correlation between changes in quantitative C-reactive protein (CRP) level with ventilator length of use | 30 days from admission | Correlation between changes in quantitative C-reactive protein (CRP) level with ventilator length of use: \< 7 days or \>7 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ventilator length of use | 30 days from admission | duration of first ventilator use until patient is extubated or deceased: \<7 days or \>7 days |
| Changes in quantitative C-reactive protein (CRP) levels | 5 days from admission | Measurement of quantitative CRP from day 1 admission to ICU using ventilator to day 5 in mcg/mL Score for changes in diaphragm thickness: 0 : no changes 1. : increase in quantitative CRP \<50% 2. : increase in quantitative CRP \>50% |
| Changes in diaphragm thickness | 5 days from admission | Measurement of diaphragm thickness from day 1 admission to ICU using ventilator to day 5 in mm Score for changes in diaphragm thickness: 0 : no changes 1. : decrease thickness of \<20% 2. : decrease thickness of \>20% |
| Changes in cross-sectional area of rectus femoris muscle | 5 days from admission | Measurement of cross-sectional area of rectus femoris muscle from day 1 admission to ICU using ventilator to day 5 in cm\^2 Score for changes in diaphragm thickness: 0 : no changes 1. : decrease cross-sectional area of \<20% 2. : decrease cross-sectional area of \>20% |
| Changes in cross-sectional area of biceps brachii muscle | 5 days from admission | Measurement of cross-sectional area of biceps brachii muscle from day 1 admission to ICU using ventilator to day 5 in cm\^2 Score for changes in diaphragm thickness: 0 : no changes 1. : decrease cross-sectional area of \<20% 2. : decrease cross-sectional area of \>20% |
Countries
Indonesia
Outcome results
None listed