Perinatal Depression
Conditions
Brief summary
The goal of the project is to evaluate for the first time, the effectiveness of using a telehealth approach to reducing perinatal depressive symptoms in diverse groups of childbearing women; urban and rural-dwelling, and from Hispanic and predominantly North European Descent populations. Pregnant women connect for one hour weekly, for 8 weeks, using their own electronic device, from whatever location they choose (e.g. home), to attend videoconference groups facilitated by a mental health professional. The approach is cost effective and reduces barriers to access to mental health services, particularly for women living in rural, low-resource, and minority communities, and those without adequate transportation, financial resources, childcare, or work release time.
Detailed description
Perinatal depression (PD) affects 12-15% of women and contributes to adverse outcomes, e.g. preterm birth, low birth weight, and impaired cognitive development of the child. Screening optimizes the detection of PD, but does not reduce barriers to mental health services (MHS) encountered by women who screen positive. A known shortage of MHS across the nation is a significant barrier, particularly in low resource and rural settings. Telehealth is a promising approach to reducing barriers, but there is little research on the effectiveness of telehealth to reduce perinatal depressive symptoms (PDS). There is high potential for telehealth to deliver effective, lower cost MHS to childbearing women, particularly those in low resource settings. The proposed project is a randomized controlled trial among women with mild to moderate PDS. The project aims to evaluate; 1) the effectiveness of a group mental health videoconference intervention (VCI) to reduce PDS across pregnancy and postpartum, and (2) differences in PDS between diverse groups of childbearing women: rural and urban-dwelling, and Latina and predominantly North European Descent (NED) populations. The investigators hypothesize that women participating in the VCI will have significantly lower PDS across pregnancy and postpartum than women in an equivalent attention control (AC) group, and the results will differ between diverse groups. A total of 192 women will be enrolled; 48 in each study group. Participants are randomly assigned to study groups: VCI +standard of care, or AC + standard of care. Sessions are delivered via Utah Telehealth Network (UTN). Women in both groups attend weekly one-hour group sessions for 8 weeks using any electronic device (laptop, tablet, smart phone) from their own home. PDS is measured six times throughout enrollment--Time 1 = pre-intervention; T2 = immediately following week 9 of group intervention classes (post-intervention), T3= 2 months post-intervention; T4= 4 months post-intervention; T5 = 6 months post-intervention; T6 = 8 post-intervention. This study is the first to use a VCI to engage women in a facilitated group approach to reducing PDS, and to evaluate the impact among diverse groups. The approach is cost effective and reduces barriers to access to MHS, particularly for women living in low-resource, and minority communities, and those without adequate transportation, childcare, or work release time. The VCI can be replicated in any setting (e.g. rural or urban), and can be adapted to the needs of diverse communities. The study advances the field by establishing whether a group telehealth intervention reduces PDS, and whether this differs based on the population. If effective and implemented broadly, far fewer women and families would suffer the negative consequences of depression. The project is in line with NINR's high priority areas, including the use of technology to promote health, and a focus on self-management and symptom science.
Interventions
UPLIFT is based on cognitive behavioral therapy and mindfulness-based practices. Participants meet by videoconference using any electronic device (laptop, tablet, smart phone) from their own home.
Program is based on standard prenatal, childbirth, infant feeding, and parenting education curriculum. Participants meet by videoconference using any electronic device (laptop, tablet, smart phone) from their own home.
Sponsors
Study design
Intervention model description
randomized controlled trial
Eligibility
Inclusion criteria
* women age 18 and older * have a viable pregnancy (any gestational age) or postpartum (up to 6 months) * have an Edinburgh Postpartum Depression Scale (EPDS) score between 9 and 20 * are English or Spanish speaking * are receiving clinical services at a collaborating prenatal or public health clinic associated with the U of Utah or Utah rural Health Districts
Exclusion criteria
* women who have an EPDS score less than 9 or greater than 20 * have a current diagnosis of a serious mental illness, such as psychosis, schizophrenia, bipolar disorder, severe depression, suicidal ideation, homicidal ideation * begun taking or changed dosage of any medications for a mental health condition within the previous 6 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Depressive Symptoms Over Time | Time 1 = pre-intervention (Baseline); T2 = immediately following week 9 of group intervention classes (Post), T3= 2 months post-intervention; T4= 4 months post-intervention; T5 = 6 months post-intervention; T6 = 8 post-intervention | Self-completed: Edinburgh Postnatal Depression Scale measures depression symptoms during pregnancy and postpartum. The instrument will measure depressive symptoms at 6 time points during pregnancy and postpartum. The instrument is on a scale of 0-30, with 0 indicating no symptoms, and 30 indicating the highest severity of symptoms. Scores \< 10 = no depressive symptoms; 10-15 = mild; 16-20 = moderate; \> 20 = severe. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Anxiety Symptoms Over Time | Time 1 = pre-intervention; T2 = immediately following week 9 of group intervention classes (post-intervention), T3= 2 months post-intervention; T4= 4 months post-intervention; T5 = 6 months post-intervention; T6 = 8 post-intervention | Self-completed: Generalized Anxiety Disorder - 7 Item scale measures symptoms of anxiety. The instrument will measures anxiety symptoms at 6 time points during pregnancy and postpartum. The instrument is on a scale of 0-21, with 0 indicating no symptoms, and 21 indicating the highest severity of symptoms. Scores of \< 5 = no anxiety; 5-9 = mild; 10-14 = moderate; \> 15 = severe. |
Countries
United States
Participant flow
Recruitment details
During the period from May 1, 2020 through May 31, 2022, 535 women were reached out to for participation in the study. Participants were recruited from University of Utah UHealth clinics as well as rural health districts.
Pre-assignment details
Out of the 535 women reached out to, 331 were unable to be contacted after four attempts. Of the remaining 204, 58 were ineligible for a combination of non-mutually exclusive factors including mental health diagnoses (n= 35), medication changes in the last 6 weeks (n=15), \>6 months postpartum (n=9), and other (n=6). Of the 147 who remained eligible to participate, 99 were consented. Of these, 17 were lost to contact prior to randomization, and 81participants were randomized.
Participants by arm
| Arm | Count |
|---|---|
| UPLIFT Program Weekly one-hour group sessions for 10 weeks facilitated by a mental health professional.
UPLIFT Program: UPLIFT is based on cognitive behavioral therapy and mindfulness-based practices. Participants meet by videoconference using any electronic device (laptop, tablet, smart phone) from their own home. | 40 |
| Pregnancy Skills Group Weekly one-hour group sessions for 10 weeks facilitated by a registered nurse.
Attention Control Group: Program is based on standard prenatal, childbirth, infant feeding, and parenting education curriculum. Participants meet by videoconference using any electronic device (laptop, tablet, smart phone) from their own home. | 41 |
| Total | 81 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 |
|---|---|---|---|
| Overall Study | Became Ineligible | 2 | 5 |
| Overall Study | Withdrawal by Subject | 6 | 6 |
Baseline characteristics
| Characteristic | UPLIFT Program | Pregnancy Skills Group | Total |
|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical Between 18 and 65 years | 40 Participants | 41 Participants | 81 Participants |
| Age, Continuous | 30 years | 31 years | 31 years |
| Ethnicity (NIH/OMB) Hispanic or Latino | 2 Participants | 6 Participants | 8 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 28 Participants | 28 Participants | 56 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 10 Participants | 7 Participants | 17 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 1 Participants | 2 Participants | 3 Participants |
| Race (NIH/OMB) Asian | 0 Participants | 1 Participants | 1 Participants |
| Race (NIH/OMB) Black or African American | 1 Participants | 0 Participants | 1 Participants |
| Race (NIH/OMB) More than one race | 3 Participants | 5 Participants | 8 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 1 Participants | 0 Participants | 1 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 6 Participants | 9 Participants | 15 Participants |
| Race (NIH/OMB) White | 28 Participants | 24 Participants | 52 Participants |
| Region of Enrollment United States | 40 participants | 41 participants | 81 participants |
| Sex: Female, Male Female | 40 Participants | 41 Participants | 81 Participants |
| Sex: Female, Male Male | 0 Participants | 0 Participants | 0 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 40 | 0 / 41 |
| other Total, other adverse events | 0 / 40 | 0 / 41 |
| serious Total, serious adverse events | 0 / 40 | 0 / 41 |
Outcome results
Change in Depressive Symptoms Over Time
Self-completed: Edinburgh Postnatal Depression Scale measures depression symptoms during pregnancy and postpartum. The instrument will measure depressive symptoms at 6 time points during pregnancy and postpartum. The instrument is on a scale of 0-30, with 0 indicating no symptoms, and 30 indicating the highest severity of symptoms. Scores \< 10 = no depressive symptoms; 10-15 = mild; 16-20 = moderate; \> 20 = severe.
Time frame: Time 1 = pre-intervention (Baseline); T2 = immediately following week 9 of group intervention classes (Post), T3= 2 months post-intervention; T4= 4 months post-intervention; T5 = 6 months post-intervention; T6 = 8 post-intervention
Population: Number Analyzed differs from Overall Number of Participants Analyzed due to participants becoming ineligible, withdrawing, and opting to not complete surveys at certain time points.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| UPLIFT Program | Change in Depressive Symptoms Over Time | Baseline | 11.11 units on a scale | Standard Deviation 3.85 |
| UPLIFT Program | Change in Depressive Symptoms Over Time | Post | 7.34 units on a scale | Standard Deviation 2.79 |
| UPLIFT Program | Change in Depressive Symptoms Over Time | 2 months | 8.84 units on a scale | Standard Deviation 3.45 |
| UPLIFT Program | Change in Depressive Symptoms Over Time | 4 months | 8.52 units on a scale | Standard Deviation 4.62 |
| UPLIFT Program | Change in Depressive Symptoms Over Time | 6 months | 8.16 units on a scale | Standard Deviation 5.52 |
| UPLIFT Program | Change in Depressive Symptoms Over Time | 8 months | 6.70 units on a scale | Standard Deviation 2.9 |
| Pregnancy Skills Group | Change in Depressive Symptoms Over Time | 6 months | 6.35 units on a scale | Standard Deviation 4.49 |
| Pregnancy Skills Group | Change in Depressive Symptoms Over Time | Baseline | 10.52 units on a scale | Standard Deviation 4.52 |
| Pregnancy Skills Group | Change in Depressive Symptoms Over Time | 4 months | 7.10 units on a scale | Standard Deviation 4.8 |
| Pregnancy Skills Group | Change in Depressive Symptoms Over Time | Post | 7.69 units on a scale | Standard Deviation 3.92 |
| Pregnancy Skills Group | Change in Depressive Symptoms Over Time | 8 months | 6.33 units on a scale | Standard Deviation 3.88 |
| Pregnancy Skills Group | Change in Depressive Symptoms Over Time | 2 months | 8.90 units on a scale | Standard Deviation 5.31 |
Change in Anxiety Symptoms Over Time
Self-completed: Generalized Anxiety Disorder - 7 Item scale measures symptoms of anxiety. The instrument will measures anxiety symptoms at 6 time points during pregnancy and postpartum. The instrument is on a scale of 0-21, with 0 indicating no symptoms, and 21 indicating the highest severity of symptoms. Scores of \< 5 = no anxiety; 5-9 = mild; 10-14 = moderate; \> 15 = severe.
Time frame: Time 1 = pre-intervention; T2 = immediately following week 9 of group intervention classes (post-intervention), T3= 2 months post-intervention; T4= 4 months post-intervention; T5 = 6 months post-intervention; T6 = 8 post-intervention
Population: Number Analyzed differs from Overall Number of Participants Analyzed due to participants becoming ineligible, withdrawing, and opting to not complete surveys at certain time points.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| UPLIFT Program | Change in Anxiety Symptoms Over Time | Baseline | 6.97 units on a scale | Standard Deviation 3.01 |
| UPLIFT Program | Change in Anxiety Symptoms Over Time | Post | 5.17 units on a scale | Standard Deviation 3.34 |
| UPLIFT Program | Change in Anxiety Symptoms Over Time | 2 months | 6.31 units on a scale | Standard Deviation 4.04 |
| UPLIFT Program | Change in Anxiety Symptoms Over Time | 4 months | 5.45 units on a scale | Standard Deviation 3.34 |
| UPLIFT Program | Change in Anxiety Symptoms Over Time | 6 months | 4.74 units on a scale | Standard Deviation 4.18 |
| UPLIFT Program | Change in Anxiety Symptoms Over Time | 8 months | 4.35 units on a scale | Standard Deviation 2.68 |
| Pregnancy Skills Group | Change in Anxiety Symptoms Over Time | 6 months | 4.74 units on a scale | Standard Deviation 4.18 |
| Pregnancy Skills Group | Change in Anxiety Symptoms Over Time | Baseline | 6.97 units on a scale | Standard Deviation 3.01 |
| Pregnancy Skills Group | Change in Anxiety Symptoms Over Time | 4 months | 5.45 units on a scale | Standard Deviation 3.34 |
| Pregnancy Skills Group | Change in Anxiety Symptoms Over Time | Post | 5.17 units on a scale | Standard Deviation 3.34 |
| Pregnancy Skills Group | Change in Anxiety Symptoms Over Time | 8 months | 4.35 units on a scale | Standard Deviation 2.68 |
| Pregnancy Skills Group | Change in Anxiety Symptoms Over Time | 2 months | 6.31 units on a scale | Standard Deviation 4.04 |