The Effect of Iodine and BPA on AITD in Reproduction Women
Conditions
Keywords
iodine, bisphenol A, autoimmune thyroid disease
Brief summary
Autoimmune thyroid disease (AITD) is the main cause of hypothyroidism in reproduction women, iodine and bisphenol A are the environmental factors for AITD. The research was mainly designed to investigate the effect of iodine and BPA on AITD in reproduction women to provide new evidence for hypothyroidism in reproduction women.
Detailed description
71 patients with thyroid autoantibody positive were treated as AITD group, another 71 healthy reproduction women were selected as normal group. Women age, BMI, thyroid disease history, family history, marital and reproductive history, whether the application of iodized salt, thyroid function and thyroid autoantibodies detection were recorded. Meanwhile urine iodine, urinary iodine/urinary creatinine, urine BPA and urinary BPA/creatinine were tested. The urine iodine and BPA levels of the two groups were compared. Taking AITD as the dependent variable, logistic regression was conducted to analyze whether urinary iodine and BPA were risk factors of AITD.
Interventions
OTHERurinary iodine and urine BPA
urinary iodine and urine BPA
Sponsors
Xiaomei Zhang
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
1. AITD group: positive thyroid autoantibody (one thyroid autoantibody), normal thyroid function. 2. Normal group: thyroid autoantibody negative, normal thyroid function. 3. No previous history of hyperthyroidism or hypothyroidism, no history of thyroid surgery or I131 radiotherapy, and no thyroid hormone or anti-thyroid drugs were used.
Exclusion criteria
1. Patients with severe liver, kidney, heart and other important organ failure. 2. Merger with other autoimmune diseases. 3. Amiodarone, iodine contrast agent and other drugs affecting thyroid function are used.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of urinary iodine levels between the two groups | 2019-2011 | Urinary iodine levels were compared between patients with autoimmune thyroid disease and normal women. |
| Comparison of urinary BPA levels between the two groups | 2019-2011 | Urinary BPA levels were compared between patients with autoimmune thyroid disease and normal women. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Influencing factors of autoimmune thyroid diseases. | 2019-2012 | Abnormal levels of iodine and PBA are influential factors in autoimmune thyroid disease. |
Countries
China
Contacts
Primary Contactjun zhao
Outcome results
None listed