Aging, Insulin-like Growth Factor 1, UVB Phototherapy Burn
Conditions
Brief summary
This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.
Interventions
Growth factor protein
OTHERNo Insulin-Lie Growth Factor 1
No Insulin-Like Growth Factor 1 will be given.
Sponsors
Wright State University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Male/Female * White skin (Fitzpatrick types I and II) * Age 21-30 or 65 and older * Able to comprehend procedures/risks
Exclusion criteria
* Known photosensitivity * Currently on photosensitizing medications * Diabetes Mellitus * History of abnormal scarring * History of skin infections * Known allergy to lidocaine local anesthetic * Pregnancy or nursing * Other serious health issues
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in expression genes involved in protecting skin cells from UVB damage in younger skin and geriatric skin injected with IGF-1 from baseline | 2 Days | Expression genes involved in protecting skin cells from UVB damage, including p21, xeroderma pigmentosum (XPC), and polymerase eta, will be higher following UVB exposure in younger skin and geriatric skin injected with IGF-1 than in geriatric skin injected with saline as a control. |
Countries
United States
Contacts
Primary ContactManager, Clinical Research Operations
Backup ContactRegulatory Specialist
Outcome results
None listed