Postoperative Delirium
Conditions
Brief summary
Delirium is a common neurologic complication after cardiac surgery occuring in 30-50% of patients. The occurence of this complication is associated with worse outcomes, including prolonged length of stay in the ICU and hospital, increased morbidity and mortality. Considering great clinical significance of this complication, the search for early predictors of postoperative delirium remains an urgent task. The purpose of this prospective observational study is to test the hypothesis that metabolomic changes before and after cardiac surgery could be served as early predictors of this complication.
Interventions
DIAGNOSTIC_TESTMetabolomic analysis
Blood will be collected in all patients blood before surgery and after surgery (postoperative day 1). Our study is based on a polar metabolomics profiling of plasma and/or serum using hybrid triple quadrupole mass spectrometer coupled with chromatographic system.
Sponsors
Novosibirsk State University
Meshalkin Research Institute of Pathology of Circulation
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* surgery under cardiopulmonary bypass * Age \> 60 years * CABG surgery or valve surgery (repair/replacement)
Exclusion criteria
* urgent surgery * surgery on aorta * combined procedures (CABG+valves) * significant stenosis of carotid arteries * Parkinson's disease * liver cirrhosis * use of anticholinergic drugs, antidepressants, antiepileptic or chemotherapy drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative delirium | 5 days after surgery | Postoperative delirium will be diagnosed with CAM-ICU (confusion assessment method - intensive care unit) |
Countries
Russia
Contacts
Primary ContactVladimir Lomivorotov, MD, PhD
Backup ContactGleb Moroz
Outcome results
None listed