Progesterone Resistance, Threatened Abortion
Conditions
Brief summary
To decide whether progesterone supplementation in threatened abortion is a sound practice.
Detailed description
This study was conducted at Obstetrics and Gynecology Department, Tanta University in the period from January 2018 to December 2018. Patients: Eligible patients (n=190) were randomly allocated into 2 groups; study group who will receive progesterone supplementation (Prog.group) and control group who will receive no treatment (place.group).
Interventions
DRUGProgesterone
received rectal progesterone suppositories 400 mg once daily
DRUGPlacebos
received placebo suppositories rectally once daily.
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* threatened abortion diagnosed by history and ultrasound examination * singleton * viable fetus * gestational age \< 20 weeks * closed normal length cervix.
Exclusion criteria
* short cervix \<2 cm Multiple pregnancy * dead fetus * open cervix ≥ 2cm * history of cervical surgery * refusal to participate.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| relief of pain | 3 weeks | questionnaire fulfilled by patient with yes or no questions |
| completion of pregnancy beyond 20 weeks | 12 weeks | passing the age 20 weeks |
| Stoppage of bleeding | 3 weeks | Cessation of bleeding |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| abortion less than 20 weeks. | 12 weeks | Abortion |
Countries
Egypt
Outcome results
None listed