Gastrointestinal Lymphoma
Conditions
Brief summary
This is a observational study on the fecal microbiota in primary/secondary gastrointestinal lymphoma patients.
Detailed description
This observation study is aimed at investigating the gut microbiota alteration in gastrointestinal lymphoma (GIL) patients by performing metagenomic shotgun sequencing on GIL patients' fecal specimen. Before immuno-chemotherapy, the feces specimen of GIL would be collected and stored for further laboratory examination. This study would NOT alter the subsequential treatment of the patients.
Interventions
DIAGNOSTIC_TESTMetagenomic shotgun sequencing
preforming metagenomic shotgun sequencing on patients' or volunteers' feces specimen
Sponsors
Ruijin Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Gastrointestinal lymphoma with a clarified pathological diagnosis * De novo gastrointestinal lymphoma patients who haven't received chemotherapy * BMI in normal range
Exclusion criteria
* Antibiotics or probiotics application within a month * Overweight (BMI≥25) or malnourished (BMI\<18.5) patients * Patients who have been accepted gastrointestinal fistulation * Gastrointestinal patients with inflammatory bowel disease (IBD), colorectal carcinoma (CRC) or any other chronic intestinal disease * Patients infected by HIV
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metagenomic Linkage Groups (MLGs) | 2 years | A serial of genes in a metagenome that is probably physically linked as a microbial unit. |
Countries
China
Contacts
Primary ContactPengpeng Xu, MD. PhD.
Backup ContactMingci Cai, Master
Outcome results
None listed