Dose-effect Relationship Between microRNAs in Peripheral Blood and Radiation Injury

Study on Dose-effect Relationship Between Radiation Injury Dose and Expression of Associated microRNAs in Human Peripheral Blood

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03928782

Enrollment

Registered

2019-04-26

Start date

2018-12-01

Completion date

2019-09-01

Last updated

2019-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Radiation Injuries, Experimental

Keywords

Radiation Injuries, microRNA

Brief summary

Rapid and accurate assessment of radiation injury dose is the key to success in early treatment and an urgent issue to be solved in clinical medicine.Researches showed that the expression of the microRNAs in human peripheral blood had much correlation with radiation injury resulted from different dosages of radiation.In this study,acute leukemic patients who will be pretreated by whole-body radiation are taked as the object of study,and biochip technology are adopted to detect the expression levels of the microRNAs in subject peripheral blood before-and-after radiation,and different expression is tested and Bioinformatics prediction,to evaluate the correlation between radiation injury dose and expression levels of the microRNAs in human peripheral blood.

Interventions

RADIATION5 Gy or 10 Gy units of whole-body radiation

8 subjects will be received 5 Gy units of whole-body radiation or 10 Gy units of whole-body radiation.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Inclusion criteria

* subjects who suffer from acute leukemic subjects who accept chemotherapy within one month and will be pretreated by whole-body irradiation peripheral blood cells of subjects are approximate to those of healthy person aged between 18 and 50 years old subjects who are competent to give written informed consent subjects without other systemic diseases

Exclusion criteria

* subjects who suffer from serious other systemic diseases subjects who are unwilling or unable to cooperate with this clinical study other serious cases that probably hinder this clinical study

Design outcomes

Primary

Measure	Time frame	Description
expression levels of the microRNAs	12 hours	the expression levels of the microRNAs in human peripheral blood before radiation，12 hours after radiation and 24 hours after radiation

Countries

China

Contacts

Primary ContactGuo biao, master

418406096@qq.com0086-010-66947095

Backup ContactLu rongjian, doctor

13426301158@163.com0086-010-66947334

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026