Pre-Eclampsia
Conditions
Brief summary
Magnesium sulphate is an inorganic salt with multiple therapeutic applications in medicine it has been widely utilized and studied on a diverse set of conditions such as asthma, cardiac arrhythmia and stroke. In pregnant women ,MgSo4 has been used in many cases such as for seizures prophylaxis in preeclampsia, tocolysis in preterm labour and for fetal neuroprotection in immenint preterm delivery.MgSo4 has been used as the standard drug for tocolysis in preterm labour and other drugs have been compared to it.
Interventions
DRUGMagnesium Sulfate
4 gram MgSo4 diluted in 150 cc saline infused IV within 30 minutes as loading dose then the patient will receive the maintenance dose of 1gram MgSo4 per hour for 6 hours.
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
pregnant women 34 weeks or less admitted to Women's Health Hospital with a diagnosis of : * sever preeclampsia. It is defined as 1- blood pressure 160/110 mmHg or more 2- proteinurea (+3 or more by dipstick) 3-HELLP syndrome * threatened preterm labour that will receive Magnesium Sulphate either for tocolysis or neuroprotection.
Exclusion criteria
\- women with more than 34 weeks gestation and with any contraindication for Magnesium Sulphate intake like severe renal impairment or myasthenia gravis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the percentage of women reaching the Mg therapeutic level. | 24 hours | the Mg therapeutic level of 4,8 mg/dl. |
Countries
Egypt
Outcome results
None listed