Dexmedetomidine
Conditions
Brief summary
The brain protection effect of dexmedetomidine has been approved in several studies. Basically, the anti-inflammatory effects and reducing catecholamines are thought to be a main role of the protection effect. In many studies reported the advantage of dexmedetomidine as a substitution of other sedative drugs for anesthesia. The anesthesia of intra-cranial aneurysmal clipping operation commonly use intravenous anesthetic agents combined with inhalation anesthesia for neuroprotection, and mostly propofol is used. The aim of this study is to examine the effects of dexmedetomidine on serum inflammatory markers and research the hemodynamic stability of dexmedetomidine compared to propofol in aneurysmal clipping operation.
Interventions
DRUGDexmedetomidine
Dexmedetomidine 0.7 ug/kg/h with sevoflurane 0.5 MAC and remifentanil infusion are used throughout anesthesia period
DRUGPropofol
Effect site concentration of propofol 1.5 ng/ml with sevoflurane 0.5 MAC and remifentanil infusion are used throughout anesthesia period
Sponsors
Ajou University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* ASA class I,II patient needs operation of intracranial aneurysmal clipping without SAH
Exclusion criteria
* Any history of neurologic disease, dementia * Allergic history of propofol or dexmedetomidine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The concentration of inflammatory markers | Baseline: Before injection study drugs | CRP (mg/ml) |
| The concentration of norepinephrine | Baseline: Before injection study drugs | NE (nmol/l) |
Secondary
| Measure | Time frame |
|---|---|
| The frequency of hypotension or hypertension | during operation |
Outcome results
None listed