Influence of Ethnical Differences on the Egg Cell Collected in Patients Undergoing Fertility Treatment

Influence of Ethnical Differences on the Oocyte Yield in Patients Undergoing IVF / ICSI Treatment in Different Countries

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03927417

Enrollment

1117

Registered

2019-04-25

Start date

2019-04-30

Completion date

2020-10-31

Last updated

2021-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

oocyte yield, ethnicity, ovarian stimulation

Brief summary

Investigators wants to analyze the differences considering the country of origin, ethnicity, characteristics, reproductive history and habits of participants undergoing in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) treatment as well as the stimulation outcome in regards to stimulation dosages and egg cell yield.

Detailed description

Infertility is acknowledged worldwide as a major health concern with significant regional differences. The prevalence of infertility in women of reproductive age has been estimated to be one in every seven couples in the western world and one in every four couples in developing countries. Geographical, sociocultural / religious and ethnical dissimilarities contribute to these global variations in infertility prevalence. Infertility has a major impact on family stability in many cultures, especially in developing countries, where childlessness can impact sociocultural status. So far, most fertility treatments are based on studies performed in Western countries and therefore mostly performed in Caucasian population and research regarding infertility causes and optimal treatments in other populations is scarce. The aim of this prospective study is therefore to analyze the differences in the basic parameters of the populations analyzed, considering the country of origin and ethnicity undergoing IVF/ICSI treatment as well as the stimulation outcome in regards to stimulation dosages and oocyte yield.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

• Couples with primary / secondary infertility who are planned to undergo IVF / ICSI treatment in one of the above mentioned centers and who agree to take part in this study.

Exclusion criteria

* Couples planned for oocyte and sperm donation * Couples in whom the female partner has a history of: * Chemotherapy or radiation which impacts the ovarian reserve * Surgery at the ovaries / adnex region * Tubal ligation * Reversal of tubal ligation * Endometriosis * Couples in whom the male partner has a history of: * Chemotherapy / Radiation which impacts the semen result * Surgery at the testicles * Vasectomy * Surgery for reversal of vasectomy

Design outcomes

Primary

Measure	Time frame	Description
Number of retrieved oocytes	1 day	Number of retrieved oocytes
Number of mature oocytes	1 day	Number of mature oocytes
Fertilization rate	1 day	Fertilization rate (% of fertilized oocytes per metaphase II oocytes injected in case of ICSI / per metaphase II oocytes inseminated in case of IVF)

Countries

United Arab Emirates

Outcome results