Diagnostic Yield, Freezing Time, Safety, Transbronchial Cryobiopsy
Conditions
Keywords
Transbronchial Cryobiopsy, freezing time, Diagnostic Yield, Safety, Diffuse Parenchymal Lung Disease
Brief summary
Transbronchial cryobiopsy in different freezing time is performed in patients with undefined diffuse parenchymal lung diseases, and assess the diagnostic yield and safety.
Detailed description
Transbronchial cryobiopsy in different freezing time is performed in patients with undefined diffuse parenchymal lung diseases, and assess the diagnostic yield and safety. This is a prospective randomized control trial.
Interventions
PROCEDURETransbronchial Cryobiopsy
Transbronchial Cryobiopsy in the Diagnosis of Diffuse Parenchymal Lung Diseases
Sponsors
Guangzhou Institute of Respiratory Disease
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. The patients are admitted in the institution as DPLD, while undefined after thorough history collection, laboratory examination and radiological data. 2. Transbronchial cryobiopsy(TBCB) is indicated by clinicians for definitive diagnosis and patients are content with the examination with agreement signed. 3. Blood gas analysis, routine blood test, ECG examination, coagulation function, immunological examination, chest HRCT, and liver/kidney function test have been completed.
Exclusion criteria
1. The radiological data indicates non-DPLD 2. The clinical examinations mentioned above are not completed. 3. The patient cannot endure or does not agree the procedure.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnotic yield | two weeks | Percentage of definitive pathological diagnosis by transbronchial cryobiopsy, the alteration of original diagnosis after transbronchial cryobiopsy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Complication rate | one week | Incidence of bleeding, pneumothorax (during the procedure and within 7 days after the intervention) and exacerbations of DPLD related to the transbronchial cryobiopsy |
Countries
China
Contacts
Primary ContactXiaobo Chen, master
Backup ContactShiyue Li, master
Outcome results
None listed