Diabetic Macular Edema, Glaucoma and Ocular Hypertension, Intravenous Drug Usage, Optic Disk Disorders
Conditions
Keywords
Diabetic maculopathy, dexamethasone implant, optic disc, vascular endothelial growth factor
Brief summary
This study evaluates the effect of dexamethasone implant which is an intraocular corticosteroid on the optic nerve fibers. Retinal nerve fiber thicknesses and optic nerve head pitting rates were measured before and 6 months after the injection.
Detailed description
Diabetic macular edema is the most frequent ocular complication of diabetes resulting in irreversible loss of vision if untreated. Dexamethasone implant implant is used to treat macular edema due to diabetes. It stay in the vitreous for 6 months after intravitreal administration. Dexamethasone implant can lead to retinal nerve fiber layer and optic nerve damage by both increasing intraocular pressure and its direct effect on neural tissue during the effective 6-month period.
Interventions
PROCEDUREintravitreal dexamethasone implant application
Peripapillary RNFL thickness measurements and colored fundus photographs were compared before and 6 months after intravitreal DEX implant injection. The cup-to-disc ratios of fundus photographs were calculated using the Image-J program.
Sponsors
Bulent Ecevit University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Patients who underwent first time intravitreal injection
Exclusion criteria
Previously received any surgery Proliferative diabetic retinopathy Glaucoma or glaucoma suspicion Optic disc fatigue Optic disc edema Uveitis and media opacity Blurred of image clarity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peripapillary RNFL thickness measurements | six month | micrometer |
Countries
Turkey (Türkiye)
Outcome results
None listed