Cough
Conditions
Brief summary
The purpose of this study is to test whether the three-seeds mixture tea reduces sputum and/or cough in COPD patients, and if so, to evaluate whether the three-seeds mixture changes the lung microbiome.
Interventions
DIETARY_SUPPLEMENTThree-seeds mixture
mixture of white mustard seeds, radish seeds and beefsteak plant (Korean perilla, a species of Perilla in the mint family, widely cultivated and edible for humans; a daily food for Korean people; many Japanese people drink as tea) seeds
DIETARY_SUPPLEMENTControl
warm water with negligible amount of the three-seeds mixture
Sponsors
Dr. Robert Jackson
Veterans Affairs Medical Center, Miami
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Males or females ages 50-80 at the time of entry 2. Non-smoker for at least 1 year 3. Chronic bronchitis with Fev1 \<80% and Fev1/ Fvc \<0.7 and daily sputum production 4. Documentation of COPD. We define COPD as the presence of irreversible airflow obstruction, presence of emphysema on CT scan or both. This determination will be by the pulmonary physicians leading this study. 5. Ability and willingness to provide informed consent.
Exclusion criteria
1\. Current Smoker 2. Asthma or other respiratory diseases 3. Frail patients (unintended weight loss, long term fatigue). 4. Patients with acute COPD exacerbation \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sputum and cough score | One month | Sputum and cough measured by Cough and Sputum Assessment Questionnaire. The minimum score of this questionnaire is 0, and the maximum score is 100, with lower scores indicating higher symptom/impact levels. The total score will be reported. The score will be summed to a total score. |
Outcome results
None listed