Type 2 Diabetes Mellitus
Conditions
Keywords
yoghurt, vitamins B, body weight, glycemic control
Brief summary
The study investigates the effects of consumption of yoghurt enriched with vitamins B compared to plain yoghurt, on body weight management and glycemic control of overweight/obese T2DM patients. It also investigates the effect of plain yoghurt consumption on gut hormones response of T2DM patients.
Detailed description
In a large number of epidemiological studies, low-fat dairy consumption has been associated with lower risk of T2DM. However, the number of randomized clinical trials which examine the impact of yoghurt consumption on glycemic control and body weight management of T2DM patients is small and include yoghurts fortified with vitamin D or probiotics. According to our knowledge, fortification of yoghurt with other classes of vitamins beyond vitamin D has not been examined. Vitamins of B-complex hold key-role in energy metabolism. In the state of diabetes mellitus, the requirements for this vitamin class may be higher because of their water solubility and increased excretion. Two groups of patients participated in the study. One group received yoghurt enriched with vitamins B and one group received isocaloric plain yoghurt. In addition, in order to investigate the effect of plain yoghurt on gut hormones, responses to a mixed meal tolerance test were evaluated in the beggining and the end of the dietary intervention.
Interventions
OTHERPlain yoghurt
cups of 200 g yoghurt
OTHERVitamin B yoghurt
cups of 200 g yoghurt
Sponsors
National and Kapodistrian University of Athens
Harokopio University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Intervention model description
Parallel assignment
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* BMI 27-36 * HbA1C \< 8.5% * Constant body weight and dietary habits for the last 3 months * Stable dose of oral medication for at least 3 months * Diagnosed with T2DM for more than 1 year
Exclusion criteria
* History of cardiovascular, gastrointestinal, renal and endocrinological diseases * Treatment for weight reduction * Lactose intolerance * Allergies to milk and dairy products * Alcohol consumption (\> 2 drinks per day) * Intake of supplements * Receiving insulin
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Body weight management | 12 weeks | Change of body weight after dietary intervention |
| Glycemic control | 12 weeks | Change of fasting plasma glucose after dietary intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of ghrelin response | 12 weeks | Change of ghrelin after the 12 weeks dietary intervention |
| Change of GLP-1 response | 12 weeks | Change of GLP-1 after the 12 weeks dietary intervention |
Outcome results
None listed