Serum and Urine Ghrelin in Adult Epileptic Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03926273

Enrollment

Registered

2019-04-24

Start date

2018-06-01

Completion date

2019-02-05

Last updated

2019-04-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Keywords

epilepsy, serum ghrelin, urine ghrelin

Brief summary

Several neuropeptides have concerned with epilepsy pathogenesis, ghrelin showed an anticonvulsant effect. There is a potential relation between its level and antiepileptic drugs (AED) response.

Detailed description

Several neuropeptides have concerned with epilepsy pathogenesis, ghrelin showed an anticonvulsant effect. There is a potential relation between its level and antiepileptic drugs (AED) response. Objective: to evaluate ghrelin effect in adult epileptic patients and in response to AED. Methods: This case control study included 40 adult epileptic patients and 40 healthy controls. Participants were subjected to history taking of seizure semiology, full general and neurological examination, electroencephalography and cranial CT or MRI. Fasting serum acylated ghrelin (AG) and unacylated ghrelin (UAG) and urine AG levels were estimated to all participants by enzyme - linked immunosorbent assay (ELIZA).

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* All participants were included if their age more than or equal to 18 years. Body mass index \< 30 kg/m2, total cholesterol \< 200mg/dl, serum triglycerides \< 200 mg/dl and random blood glucose level \< 126 mg/dl.

Exclusion criteria

* Participants had acute or chronic metabolic disorders (liver, kidney, thyroid, endocrine or gastrointestinal disorders). * Females with irregular menstrual cycle or on estrogen therapy (7). * Participants with organic cerebral lesion that was detected on cranial computed tomography (CT) or cranial magnetic resonance imaging (MRI).

Design outcomes

Primary

Measure	Time frame	Description
Serum ghrelin in Adult Epileptic Patients	6 months	evaluation of the effect of Serum ghrelin in adult epileptic patients and in their response to anti- epileptic drugs
Urine ghrelin in Adult Epileptic Patients	6 months	evaluation of the effect of Urine ghrelin in adult epileptic patients and in their response to anti- epileptic drugs

Countries

Egypt

Outcome results