Knee Arthroscopy
Conditions
Brief summary
Outpatient arthroscopic knee surgery can be performed with general or regional anesthesia. Recent data suggest that spinal and epidural anesthesia require longer discharge times than the newer shorter-acting general anesthetic drugs. Ideal premedication drug should relieve anxiety, produce amnesia and sedation, decrease secretions, prevent nausea and vomiting, have dose sparing effect on the anaesthetic drugs, and suppress pressor response to laryngoscopy and intubation. Recently, gabapentin and pregabalin were suggested as pre-operative drugs to decrease anxiety, stress response to laryngoscopy and post operative pain.
Detailed description
112 patients undergoing elective knee arthroscopy will randomly divided into two equal groups, 56 patients each. All patients will receive premedication one hour before the procedure. PG group will receive 150 mg pregabalin and C group will receive placebo. All patients will receive total intravenous anesthesia to achieve optimum working conditions. Intra-operative total amount of anesthetics will be compared in both groups.
Interventions
DRUGPregabalin (PG)
Pregabalin 150 mg one hour before the procedure as premedication.
Placebo tablets one hour before the procedure as premedication.
Sponsors
Menoufia University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for elective knee arthroscopy. * Patients aged between 21 and 50 years old. * Patients with American Society of Anaesthesiologists physical status I or II.
Exclusion criteria
* Patients with known allergy to any drug used in the study. * Patients with chronic use of analgesics and/or sedatives. * Patients with sleep apnea syndrome. * Patients with renal or hepatic dysfunction. * Patients with psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total amount of anesthetics | 45 minutes during the procedure | Total amount of anesthetics used during the procedure. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patients' satisfaction: satisfaction score | 30 minutes after the end of the procedure | Patient's satisfaction score will be recorded using a score ranging from 0 not satisfied and 5 totally satisfied. The score will be done using a questioner designed by the researchers. |
Outcome results
None listed