Immune System and Related Disorders
Conditions
Keywords
immune system, environmental interactions, genetic component
Brief summary
CoSImmGEn is a protocol set up to respond to the current lack of healthy and sick population cohorts. Biological resources from these cohorts allow researchers to study the immune system and its genetic and environmental determinants. Those cohorts and collections are open not only to the Pasteurian community but also to the worldwide scientific community (both public and private) working in the field.
Detailed description
The CoSImmGEn protocol is dedicated to the study of the immune system in healthy people or people with specific pathologies. It is composed of 6 arms (sub-cohorts): * Arm main cohort CoSImmGEn: comprised of 5 sub groups (A, B, C, D, M) of healthy adult subjects from various ethno-geographical origins. * Arm ancillary cohort P comprised of first-degree relatives (including parents, siblings, or children), whether they are healthy or ill. It will allow, whenever necessary, to remove allelic ambiguities for example for the study of HLA and MHC genes. * Arm ancillary cohort HS: comprised of subjects suffering from Suppurativa Hidradenitis (or Verneuil's disease.) The investigators will include patients suffering from this disease and their close relatives, in order to understand the genetic, immunological, microbiological and metabolomic bases of this disease. * Arm ancillary cohort J: comprised of elderly patients (≥ 65 years old) with Alzheimer's disease and with mild, moderate or severe cognitive impairment. It will help understand the role of the gut microbiota in age-related brain deficits. * Arm ancillary cohort F: comprised of patients with familial adenomatous polyposis and carrying a mutation of the APC (Adenomatous Polyposis Coli) tumor suppressor gene. That arm has been set up to carry out a pilot phase on the role of APC mutations on anti-tumoral immune response. * Arm ancillary cohort I: comprised of patients with chronic inflammatory diseases such as Ankylosing spondylitis and Crohn's disease. * Arm ancillary cohort V: comprised of subjects vaccinated against COVID-19. It will help to follow-up the immune response after vaccination against COVID-19 in the general population. Additional arms may be set up through new collaborations in the next few years to study others diseases in which the immune system intervenes, such as: infectious diseases, allergies or cancers.
Interventions
PROCEDURECollection of samples (blood, stool, etc.)
GENETICGenetic determinants analysis
PROCEDURESample obtained after surgery performed in the context of care
Sponsors
Institut Pasteur
Study design
Allocation
NON_RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* unprotected adults with social security who have attested their consent after receiving any relevant information about the study * subjects whose ethno-geographical origin of both parents is known * subjects for whom data on principal vaccinations (diphtheria, tetanus, poliomyelitis, hepatitis B, possibly tuberculosis) are documented * subjects who consented to carry out serological tests HIV, HCV, HBV
Exclusion criteria
* Any conditions that would not allow participation in the present study, on the opinion of the investigator (documenting), ie any acute or chronic pathology that may interfere with the immune system, such as progressive or chronic pathology severe or uncontrolled by current treatments or a pathology requiring the administration of immune impact drugs: long-term anti-inflammatory, immunosuppressive, etc * Pregnant or lactating women * For the realization of skin biopsies: allergy to local anesthetics, cardiac valvulopathy * For the realization of Tubertest: Subject presenting a contraindication to tuberculin
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Immunological analysis | through study completion, an average of 4 year | Percentage of blood cells harbouring morphological of functional abnormalities identified by flow cytometry and TrueCulture system analysis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Genetic analysis | through study completion, an average of 4 year | Identification of genetic factors implicated in or predisposing to specific diseases through gene expression quantification, targeted genotyping of exome sequencing or whole genome sequencing. |
| Microbiota analysis | through study completion, an average of 4 year | Identification of specific compositions of intestinal and/or cutaneous microbiota associated with specific diseases by metagenomic analysis. |
| Metabolomic analysis | through study completion, an average of 4 year | Quantification of blood metabolites by mass spectrometry |
Countries
France
Contacts
Primary ContactMarie-Noelle Ungeheuer, PhD
Backup ContactHélène Laude, PhD
Outcome results
None listed