Chronic Periodontitis
Conditions
Keywords
zinc, Non-surgical Periodontal Therapy, stage II periodontitis, stage III periodontitis, gingival crevicular fluid, total oxidant capacity, Type 2 diabetic patients
Brief summary
To evaluate the effect of systemic administration of zinc on the gingival crevicular fluid level of total oxidant capacity in controlled Type-2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal therapy.
Detailed description
Hypozincaemia and hyperzincuria is known to be present in patients with type-2 diabetes, and Zinc supplementation is known to be helpful in restoring plasma Zinc levels to normal,Zinc's deficiency can lead to an increase in circulating glucose due to beta cells malfunctioning and resistance to insulin, which makes it easier for type 2 diabetes mellitus (DM2) to happen ,Zinc was found to be a structural part of key anti-oxidant enzymes such as superoxide dismutase (SOD), and Zinc deficiency impaired their synthesis, leading to increased oxidative stress
Interventions
DRUGZinc Sulfate
systemic administration of Zinc sulfate with scaling and root planing
PROCEDUREscaling and root planing
scaling and root planing
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
The outcome assessor and statistician will be blinded to the intervention
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Controlled Type-2 diabetes mellitus * Stage-II &III periodontitis * At least 2 sites with clinical attachment loss 3 or 4 mm to ≥5 mm and radiographic bone loss 15% Extending to mid-third of root and beyond. * Probing depth from ≤5 mm to ≥6 mm
Exclusion criteria
* Any periodontal or Antibiotic treatment during the last six months. * Receiving trace element supplements in the previous three months * Pregnant or lactating females * Gastric or diuretic treatment * Acute renal failure * smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change from baseline Hb-A1c | change from baseline Hb-A1c at 3 monthes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hb-A1c | at the baseline and after 3 months | Hb-A1c |
| Probing pocket depth | at the baseline and after 3 months | Probing pocket depth Measured as the distance between the gingival margin and the apical part of the pocket will be measured using William's graduated periodontal probe. |
| Clinical attachment level | at the baseline and after 3 months | It will be measured from the cemento-enamel junction till the apical part of the pocket. |
| Gingival index | at the baseline and after 3 months | Gingival Index for a specific tooth == Average (points for the 4 surfaces) |
Contacts
Primary Contactabdulrahman A Abdulrab
Backup ContactDr. Enji Ahmed, professor
Outcome results
None listed