Copd
Conditions
Brief summary
Chronic Obstructive Lung Disease (COPD) is one of the leading death causes worldwide. COPD is a disease that is characterized by chronic inflammation which leads to irreversible damage of airways and lung tissue. This intervention investigates the effects of a diet high in protein and energy for the improvement of coughing capacity and lung function of COPD patients. The patients will be recruited as part of a lung rehabilitating programme which takes place in Bispebjerg and Hvidovre Hospital. The intervention group receives individual nutritional guidelines whereas the control group continues their usual diet. Blood tests will be performed at baseline and the end of the study. Other anthropometric measures include spirometry for lung function, hand grip strength and fat free mass to assess muscle waisting.
Detailed description
40 patients with COPD randomized to diet with protein 1.3 g/kg/day or habitual intake: Primary endpoint (before-after): Leicester Cough Questionnaire Secondary endpoints: ADL-score, no. daily cough periods, development in FEV1 and FVC, hand-grib-strenght, use of respiratory medications, smoking, appetite, admissions to hospital, antibiotics and/or steroids, oxygen saturation, FFM (BIA), Coughs tests in spirometer and peak-flow-meter Study period: 2 months
Interventions
DIETARY_SUPPLEMENTHigh protein and energy diet
Intervention group receives nutritional counseling to increase protein and energy in their diet to reach their estimated protein need (1.3 g/kg). Kontrol group continues their usual diet.
OTHERHabitual Diet
Patients continue their usual diet
Sponsors
Bispebjerg Hospital
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
Randomized
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosed with COPD * Participating in ongoing lung rehabilitating programme at Hvidovre and Bispebjerg Hospital * over 18 years
Exclusion criteria
* Plasma creatinin over 200 mikrog/l * dementia * unable to read or speak danish
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement of coughing capacity of COPD patients | 8 weeks | Measured by a validated danish version of Leicester Cough Questionnaire (1-7 points) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Weight change | 8 weeks | kg difference |
| Oxygen saturation before and after treatment | 8 weeks | Finger tip measurement - % of normal |
Countries
Denmark
Contacts
Primary ContactCamilla Kieffer, stud scient
Backup ContactJens R Andersen, MD, MPA
Outcome results
None listed