Allergic Disorder, Anemia in Pregnancy, Asthma, Complications, Pregnancy, Depression, Gestational Diabetes Mellitus in Pregnancy, Gestational Hypertension, Immune System Diseases, Neurodevelopmental Disorders, Obesity, Obstetric Labor Complications, Reproductive Disorder, Thyroid Disease Pregnancy
Conditions
Brief summary
The Huizhou mother-infant cohort was set up to investigate the effect of dietary factors and environmental exposures during pregnancy on health consequences of mothers and offsprings in Huizhou, China.
Detailed description
Huizhou mother-infant cohort (No-worry Baby Project) is a scientific research/public health project jointly initiated by Huizhou First Maternity and Child Healthcare Hospital and School of Public Health, Sun Yat-sen University. The project plans to recruit 10,000 participants since early pregnancy and follow up for three years after birth in the first stage. Biological samples, data from questionnaires survey and clinical information will be collected for both mothers and infants. The study is aimed to investigate the effects of dietary factors and environmental exposures during pregnancy on infants' health as well as the prognosis of diseased mothers. The study will have essentially both clinical and public health implications to find effective strategies for prevention and management of a range of chronic disorders (above mentioned) during pregnancy and exploration of the possible impacts on offspring health. The cohort will provide scientific basic for improvement of mother and infant's health.
Interventions
OTHERNo intervention
No intervention
Sponsors
Huizhou No.1 Maternal and Child Care Service Cencer
Sun Yat-sen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnant women who have plan to delivery and participate in child care in Huizhou hospital; * Pregnant women who have resided in Huizhou for at least 3 years; * Pregnant women who are consent for specimens and data collection and follow-ups for both mother and infant.
Exclusion criteria
* Pregnant women who are with gestational age more than 24 weeks ; * Pregnant women who refuse to participate or be unwilling to sign informed consent; * Pregnant women who are mentally incapacitated and need guardians.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of adverse birth outcomes. | At delivery. | Including dystocia,stillbirth, fetal macrosomia and child with birth defect. |
| Children weight changes. | At age of 1 month, 3 months, 6months, 1 year, and 3 year. | Weight is measured in kilograms. |
| Children height changes. | At age of 1 month, 3 months, 6months, 1 year, and 3 year. | Height is measured in meters. |
| Number of participant with gestational complications. | At delivery. | Including gestational hypertension and preeclampsia, and gestational diabetes mellitus. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maternal weight changes(kg). | At 20 weeks of gestation, 28 weeks of gestation, the time before labor and 30 days after delivery. | Assess using electronic weighing machine and body composition analyzer. |
| Number of participant with postnatal depression. | At 30 days after delivery. | Assess using Edinburgh Postnatal Depression Scale (EPDS). The total score of scale is 30 ,and higher score indicates worse status. |
Countries
China
Outcome results
None listed