Critical Illness, Hematologic Disease, Immunologic Deficiency Syndromes, Neoplams, Transplantation
Conditions
Brief summary
The analysis of a cohort of consecutive non-selected patients from the Strasbourg University Hospital, and therefore representative of the real life, will allow better identifying the risk factors for these infections (by comparison with a cohort of patient with similar conditions of immunosuppression and no infection) and improving the diagnosis and therapeutic management. The primary objective is to identify prognosis factors affecting survival in patients with opportunistic infections
Interventions
None listed
Sponsors
University Hospital, Strasbourg, France
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
* Non selected consecutive immunocompromised or frail patients with an opportunistic infection * Hospitalized in any of the department of the University Hospital of Strasbourg * For epidemiological study, patients with similar immunodepression of frail condition and no opportunistic infection
Exclusion criteria
\- Opposition of the patient to use his personal data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Short- and long-term survival, overall and in specific subgroups of patients | Long-term time point : 1st may 2019 |
Secondary
| Measure | Time frame |
|---|---|
| Prognosis factors in patients with opportunistic infection affecting the response to antimicrobial therapy (using response criteria defined by EORTC/MSG) | first day of opportunistic infection |
| Identification of baseline prognosis factors affecting the 3 months survival | first day of opportunistic infection |
| Identification of baseline prognosis factors affecting the 6 months survival | first day of opportunistic infection |
| Incidence of specific opportunistic infections in different host groups | evolution of a 20-year-period |
| Risk factors predisposing to opportunistic infections - age - gender - Type of work - Location - Tobacco use | first day of opportunistic infection |
| Assessment of performance of Aspergillus galactomannan detection test in serum | at onset and up to 1 week |
| Assessment of performance of Aspergillus galactomannan detection test in bronchoalveolar lavage | at onset and up to 1 week |
| Response rate | at 1, 3 and 6 months |
| Description of imaging patterns opportunistic infections: analysis of chest CT-scan and cerebral CT-scan and MRI by radiologists | at first day of infection and up to 12 weeks |
Countries
France
Contacts
Primary ContactRaoul HERBRECHT, MD
Outcome results
None listed