Smoking, Smoking, Tobacco
Conditions
Brief summary
Randomized, double-blind, before-after controlled trial to assess changes in regional brain activation in response to cigarette-related cues from before to after treatment with bupropion (vs placebo).
Interventions
DRUGBupropion
Bupropion 150 mg sustained release
OTHERPlacebo
Sponsors
University of California, Los Angeles
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Caregiver)
Masking description
Matching placebo pills
Intervention model description
Randomized, double-blind, before-after controlled trial
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Inclusion criteria
* Treatment-seeking cigarette smoker * Meet DSM-IV criteria for nicotine dependence * Negative result on urine test for drug use during screening
Exclusion criteria
* History of any Axis I psychiatric diagnosis other than nicotine dependence * Medical conditions that might affect brain function * Current use of medications that could alter brain function * Pregnancy * Current illicit drug use other than occasional use of marijuana
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Craving ratings | 8 weeks | Participants were instructed to respond from 1 (definitely not) to 5 (definitely) on the question, I crave a cigarette right now, after viewing video cues. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Exhaled carbon monoxide (CO) | 8 weeks | Participants were asked to hold their breath for as long as possible, ideally 15 seconds, then to breathe out slowly into the mouthpiece of a CO monitor, aiming to empty the lungs completely. |
| Cigarettes per day | 8 weeks | Self-reported number of cigarettes smoked daily during the past 7 days \[??\] |
| Fagerström Test for Nicotine Dependence (FTND) | 8 weeks | The FTND contains six items that evaluate the quantity of cigarette consumption, the compulsion to use, and dependence. The yes/no items are scored from 0 to 1 and multiple-choice items are scored from 0 to 3. The items are summed to yield a total score of 0-10. The higher the total Fagerström score, the more intense is the patient's physical dependence on nicotine. |
Outcome results
None listed