Body Composition, Breast Density, Mental Health Issue, Nutritional Status
Conditions
Keywords
Breast densities, Breast neoplasms, Glucose metabolism disorders, Diabetes, gestational, Pregnancy, Nutritional status, Mental health, Body composition, Growth and development, Primary Health Care, Dual-energy X-ray Absorptiometry, Latin America, Chile
Brief summary
The Chilean Maternal & Infant Cohort Study II (ChiMINCs II) is an ongoing cohort that is part of the Chilean Maternal and Infant Nutrition Observatory of the South-East area of Santiago, Chile. In total, 1927 pregnant women beneficiaries of the public health systems and their offspring were recruited before 12 weeks of gestation and are followed across pregnancy (\<15, 26-28, and 35-37 weeks of gestation) and up to 2 years of age of their offspring. Two studies are currently nested in ChiMINCs II: 1) Breast Cancer Risk Assessment in Mothers (BRECAM) study, and 2) the ChiMINCs-COVID study. The primary objective of BRECAM study is to test the association between maternal metabolic indicators (i.e., insulin, glucose, IGF-1, and HbAc1 concentrations) at early pregnancy (i.e., \<15 and 26-28 weeks of gestation) and breast density 3 months after the cessation of lactation. For this purpose, we collect maternal obstetric, lifestyle, dietary intake, anthropometric, and biochemical information. The aim of the ChiMINCs-COVID study is to assess dietary-related risks and mental health problems derived from the COVID-19 pandemic and their influence on maternal and infant's health and nutrition. Thus, we collected detailed information on dietary behaviors, mental health and COVID-related information at each trimester, along with neonatal and infant nutritional information. The purpose of the present work is to describe the design, methods, and descriptive information at recruitment of ChiMINCs-II, also discussing the implications that this study can have to better understand maternal and infant nutrition and health during the COVID-19 era.
Interventions
OTHERNutrition and mental health during pregnancy
Altered metabolic milieu is defined as a fasting glucose level \>100 mg/dL at the first trimester of pregnancy by national guidelines. Altered metabolic milieu during the second trimester (24-28 weeks of pregnancy) is defined as a fasting glucose levels \> 92 mg/dL and/or plasma glucose levels \> 153 mg/dL two hours after load in the oral glucose tolerance test according to ADA guidelines or a fasting glucose \>100 mg/dL and/or \> 140 mg/dL two hours after load in the oral glucose tolerance test according to national guidelines. The COVID-19 pandemic is considered as a natural nutritional and mental health exposure.
Sponsors
Pontificia Universidad Catolica de Chile
Servicio de Salud Metropolitano Sur Oriente
Instituto de Nutrición y Tecnología de los Alimentos
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 or more years of age * Gestation \<15 weeks at first prenatal visit * No intention to move outside the city of Santiago in the next to years
Exclusion criteria
* High-risk pregnancy (i.e., preeclampsia, pre- existing diabetes) * Pre-existing cancer or family history of breast cancer * Intended to migrate from the public to the private health care system
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pandemic Anxiety Scale | Through the gestation, up the delivery | Score |
| Pregnancy Risk Assessment Monitoring System | Through the gestation, up the delivery | Score |
| Edinburg Postnatal Depression Scale | Through the gestation, up to 6 months | Score |
| Glucose concentration | Through the gestation, up the delivery | mg/dL |
| Insulin concentration | Through the gestation, up the delivery | uIU/mL |
| Breast absolute (AFGV) fibro-glandular volume measured by DXA technique | Three months after breastfeeding cessation | cm3 |
| Breast absolute percentage (%FVG) of fibro-glandular volume measured by DXA technique | Three months after breastfeeding cessation | percentage |
| Gestational weight gain | At delivery | kg |
| Gestational Diabetes | At delivery | Percentage of mothers diagnosed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Offspring length | At 6 months of age | cm |
| Offspring head circumference | At 6 months of age | cm |
| Offspring body fat | At 6 months of age | Percentage |
| Offspring weight | At 6 months of age | g |
Countries
Chile
Outcome results
None listed