Bacterial Infections in Patients with Cirrhosis in Argentina: Clinical and Microbiological Characteristics

Conditions

Bacterial Infections, Cirrhosis, Morality, Resistant Infection

Brief summary

In recent years, there has been an increasing prevalence of bacterial infections caused by multiresistant and extremely resistant organisms in patients with cirrhosis. These infections are associated with a worse prognosis, generate difficulties in the management of the patient during hospitalization and increase health costs. The main objective of this project is to estimate the prevalence of infections by multiresistant bacteria in patients with cirrhosis. Additionally, the prevalence of other antibiotic resistance patterns and morbi-mortality in the study population will be evaluated. For these purposes, a multicenter prospective cohort study will be carried out, including patients with cirrhosis who present bacterial infections at the time of admission, or during hospitalization. Performing a study in Argentina on the clinical and microbiological characteristics of bacterial infections in patients with cirrhosis could be very useful to develop new strategies for prevention and treatment of this severe complication.

Carolina Vázquez, María Nelly Gutierrez‐Acevedo, Sabrina Barbero, Lorena del Carmen Notari, Marina Agozino et al. (48 authors)

Annals of Hepatology2023-04-0616 citations

10.1016/j.aohep.2023.101097

P-6 PATTERNS OF ANTIBIOTIC RESISTANCE IN PATIENTS WITH CIRRHOSIS AND SPONTANEOUS BACTERIAL INFECTIONS: ANALYSES OF THE MULTICENTER STUDY FROM ARGENTINA AND URUGUAY

Sebastián Marciano, Maria Nelly Gutierrez Acevedo, Sabrina Barbero, Lorena Notari, Marina Agozino et al. (48 authors)

Annals of Hepatology2023-03-01

10.1016/j.aohep.2023.100910

Norfloxacin prophylaxis effect on multidrug resistance in patients with cirrhosis and bacterial infections.

Marciano S, Gutierrez-Acevedo MN, Barbero S, Del C Notari L, Agozino M, Fernandez JL, Anders MM, Grigera N, Antinucci F, Orozco Ganem OF, Murga MD, Perez D, Palazzo A, Martinez Rejtman L, Duarte IG, Vorobioff J, Trevizan V, Bulaty S, Bessone F, Valverde M, Elizondo M, Bosia JD, Borzi SM, Stieben TE, Masola A, Ferretti SE, Arufe D, Demirdjian E, Raffa MP, Peralta M, Fainboim HA, Vazquez CE, Ruiz P, Martínez JE, Heffner LA, Odzak A, Dirchwolf M, Smud A, Mendizabal M, Bellizzi C, Martinez A, Tomatis J, Bruno A, Ramos A, Pages J, Tevez S, Gadano AC, Giunta DH.

2023-02-236 citations

10.1007/s10096-023-04572-2

O-9 COMPARISON OF THE PERFORMANCE OF DIFFERENT SCORES FOR THE PREDICTION OF IN-HOSPITAL MORTALITY IN PATIENTS WITH CIRRHOSIS AND BACTERIAL INFECTIONS

Agustina Martinez Garmendia, Maria Nelly Gutierrez Acevedo, Sabrina Barbero, Lorena Notari, Marina Agozino et al. (51 authors)

Annals of Hepatology2021-09-01

10.1016/j.aohep.2021.100496

Interventions

OTHERThis is an observational study without intervention

This is an observational study without intervention

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Patients with cirrhosis * Patients older than 17 years. * Patients who are hospitalized for bacterial infections, or who develop bacterial infections while hospitalized

Exclusion criteria

• Refusal to participate in the informed consent process

Design outcomes

Primary

Measure	Time frame
To estimate the prevalence of infections caused by multi-resistant microorganisms in patients with cirrhosis	at the moment of the diagnosis of the bacerial infection

Secondary

Measure	Time frame
To evaluate variables associated with infections caused by multi-resistant microorganisms in patients with cirrhosis	at the moment of the diagnosis of the bacerial infection
To evaluate the effect of infections caused by multi-resistant microorganisms on the in-hospital survival of patients with cirrhosis	30 days

Countries

Argentina

Outcome results

None listed