Hematologic Diseases, Stem Cell Transplantation
Conditions
Brief summary
This study is designed to assess the hypothesis that the lipopolysaccharide (LPS) activity index can be quantified early after transplantation, as well as the the PhosphoLipid Transfer Protein (PLTP) activity and these both biological variables are independent variables for predicting the risk of severe Graft versus Host Disease (GVHD).
Interventions
OTHERBlood sample
blood samples (4 times; 14ml per visit)
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Hematologic malignancy in complete remission * Patients eligible for allogeneic hematopoietic cell transplantation from a related or unrelated donor and after myeloablative or non-myeloablative conditioning. * Regular follow-up in the center
Exclusion criteria
* Treatment with a statin in progress * Umbilical cord blood transplantation * Hemoglobin level less than or equal to 8g / dl * Known chronic inflammatory bowel disease or gastroenteritis at the time of inclusion. * Chronic enteropathy with Clostridium Difficile
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Area under the ROC curve for PLTP in the occurrence of GVHD | 3 months | Area under the ROC curve (AUCROC) for PLTP assessed at day 0 (day of transplantation) in the occurrence of GVHD (grade II-IV) at 3 months post-transplant. |
| Area under the ROC curve for LPS in the occurrence of GVHD | 3 months | Area under the ROC curve (AUCROC) for LPS assessed at day 0 (day of transplantation) in the occurrence of GVHD (grade II-IV) at 3 months post-transplant. |
Countries
France
Outcome results
None listed