Ventilator Associated Pneumonia
Conditions
Keywords
ventilator associated pneumonia, lung ultrasound
Brief summary
The study evaluates whether lung ultrasound monitoring could lead to earlier detection of ventilator associated pneumonia and influence outcome. Half of the participants will be diagnosed with VAP using a combination of lung ultrasound and clinical features and half will be diagnosed using the Johanson criteria, which is a combination of clinical features and chest x-ray.
Detailed description
The current guidelines recommend the use of chest x-ray or computed tomography of the chest to aid in the diagnosis of VAP. However many studies have shown that chest x-ray is neither very sensitive nor specific for pneumonia, and computed tomography, though has the highest diagnostic accuracy, is not routinely performed due to logistics, safety concerns, economics and radiation exposure. Emerging studies including meta-analyses have shown high sensitivity and specificity of lung ultrasound in diagnosing pneumonia. When combined with clinical and microbiological features it has shown to be helpful in early diagnosis of VAP, but a study to show whether such early detection improves outcome is lacking.
Interventions
DIAGNOSTIC_TESTlung ultrasound
lung ultrasound will be performed daily in mechanically ventilated patients after 48 hours of ventilation to screen for ventilator associated pneumonia
Sponsors
Tribhuvan University Teaching Hospital, Institute Of Medicine.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Mechanical ventilation for more than 48 hours * Absence of pneumonia as the reason for mechanical ventilation (includes clinical, radiological or sonographic diagnosis)
Exclusion criteria
* Recent trauma or surgery to the thorax (including chest tube insertion) * Presence of dressings or skin conditions restricting access to the thorax * Confirmed pregnancy * If already enrolled in the study * Denial of consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ventilator free days | day 28 from diagnosis of VAP | number of days alive from day 1 (of VAP) to day 28 on which a patient breathes without assistance, if the period of unassisted breathing lasted at least 48 consecutive hours. If death occurs within 28 days then ventilator free days is counted as 0 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| icu mortality | through study completion, an average of 3 months | death during icu stay |
| icu length of stay | through study completion, an average of 3 months | total duration of stay in icu |
| delta sofa | day 4 from VAP diagnosis | change in Sequential Organ Failure Score (SOFA) at day 4 of onset of VAP from the day of onset of VAP. SOFA ranges from 0 to 24. Delta sofa is the difference between SOFA score at day 4 from day 0 of VAP diagnosis. the higher the difference, the better the outcome |
| ventilator days | day 28 from intubation | total days the patient remains in mechanical ventilation |
| antibiotic duration | day 14 from initiation of antibiotic | total days the patient receives antibiotics for VAP |
Countries
Nepal
Outcome results
None listed