Desflurane vs. Sevoflurane in Endovascular Aortic Repair

Fast-track in Endovascular Aortic Aneurysm Repair With Desflurane and Sevoflurane: a Randomized Clinical Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03917186

Enrollment

Registered

2019-04-16

Start date

2017-09-20

Completion date

2021-03-16

Last updated

2023-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Failure

Keywords

Desflurane, Sevoflurane, Endovascular aortic repair

Brief summary

Randomized Clinical Trial following the evaluation of the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery.

Detailed description

Randomized Clinical Trial to evaluate the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery. Secondary Endpoint: Among secondary endpoints we will evaluate clinical variables such emergence and recovery characteristics (time to extubation and time to emergence-open eyes and response to verbal command), the need for postoperative mechanical ventilation, the post-anesthesia recovery score and ICU length of stay.

Interventions

DRUGSevoflurane

administration of sevoflurane

DRUGDesflurane

administration of Desflurane

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* older than 18 years undergoing elective endovascular aortic repair * who have signed informed consent

Exclusion criteria

* urgent surgery * with known hypersensitivity to Desflurane or Sevoflurane. * Renal failure in hemodialysis

Design outcomes

Primary

Measure	Time frame	Description
Change in Biochemical parameters	All these parameters will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups	NGAL in urine

Secondary

Measure	Time frame	Description
Need for postoperative mechanical ventilation	24 hours	hours of mechanical ventilation in ICU
ICU length of stay	up to 24 hours	hours in ICU
anesthetic recovery	These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded at baseline and after surgery. time frame upto 1 hour(stimated)	time to extubation(minutes).

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026