Glycemic Index
Conditions
Brief summary
To quantify the glycemic index of the SP energy-smart-based nutrition supplement and the SP Glucose-support formula as compared to a glucose drink. We hypothesized that both the energy-smart-based nutritional supplement and the SP Glucose-support formula will have low glycemic index. The aim of the study is to quantify the glycemic index of the SP energy-smart-based nutrition supplement and the SP Glucose-support formula as compared to a glucose drink. We hypothesized that both the energy-smart-based nutritional supplement and the SP Glucose-support formula will have low glycemic index.
Detailed description
Subjects: 9 non-diabetic (HbA1c \< 6.5) males aged 30-55 years with body mass indices ranging from 27.5 to 35 kg∙m-2. Individuals with impaired glucose tolerance will be included as long as they are not diagnosed with diabetes and their HbA1c is less than 6.5. Preliminary Testing: Medical history, weight, height, body composition via dual x-ray absorptiometry (DXA) and glycosylated hemoglobin (HbA1c) measurement. Protocol: After a 10-hour overnight fast, subjects will complete 3 experimental visits in which they will ingest one of three beverages in a randomized order. During experimental visits subjects will either be given the following 3 experimental drinks: * Full SP-glucose balance formula (200 kcal) * Energy smart carbohydrate blend (50 g, 200 kcal) * Liquid dextrose solution in the form of TRUTOL ® Glucose Tolerance Test Beverage (50 g, 200 kcal)
Interventions
DIETARY_SUPPLEMENTCarbohydrate drink
Meal replacement drink containing 200 kcal
DIETARY_SUPPLEMENTEnergy smart Carbohydrate blend
Carbohydrate blend drink designed for low glycemic responses containing 200 kcal
DIETARY_SUPPLEMENTLiquid Dextrose
Liquid Dextrose drink of 200 kcal
Sponsors
Standard Process Inc.
Arizona State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Intervention model description
Randomized Cross-over trial
Eligibility
Sex/Gender
MALE
Age
30 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 27.5 to 35 kg∙m-2
Exclusion criteria
* Diagnosed diabetes * HbA1c \> 6.5 * competitive athletes * body weigh change \> 3kg during last month
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Area Under the Curve of Glucose | 120 minutes | Positive integer of the area under the Curve of glucose |
| Area Under the Curve for Insulin | 120 minutes | Positive integer of the area under the Curve of insulin |
| Blood glucose | 30, 60 and 120 minutes of the glucose challenge | Blood glucose levels |
| Blood insulin | 30, 60 and 120 minutes of the glucose challenge | Blood insulin levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| c-peptide | 30, 60, and 120 minutes of the glucose challenge | Blood levels of c-peptide |
| glucagon-like-peptide-1 | 30, 60, and 120 minutes of the glucose challenge | Blood levels of glucagon-like-peptide-1 |
| glucagon | 30, 60, and 120 minutes of of the glucose challenge | Blood levels of glucagon |
| Leptin | 30, 60, and 120 minutes of the glucose challenge | Blood levels of leptin |
| Adiponectin | 30, 60, and 120 minutes of the glucose challenge | Blood levels of adiponectin |
Countries
United States
Outcome results
None listed