Pain, Postoperative, Polymorphism, Single Nucleotide, Thoracic Surgery, Video-Assisted
Conditions
Brief summary
Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Different patients experience different pain intensity. This suggests that there may be genetic variants that make some patients susceptible to analgesic failure. Using blood samples from patients, the investigators are going to analyze the relationship between single nucleotide polymorphisms (SNPs) in genes that are known to be involved in analgesic failure.
Interventions
GENETICGenetic analysis
Collect 2ml intravenous blood from patients after anaesthesia.
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age ≤ 70 and Age ≥18 * Selective operation lung section with video-assisted thoracic surgery (VATS) * III ≥ American Society of Anesthesiologists classification (ASA classification) ≥I * Patients informed and agreed to join the study
Exclusion criteria
* Abnormal function of liver and kidney * Allergic- dependence history of alcohol, opioids and Local anesthetics * No noncompliance * Mental disease history，language communication disorder，cicatricial diathesis * Underweight or overweight（BMI\<18 or \>30) * Patients not suitable for clinical subjects for other reasons * Sedatives, analgesics, antiemetic drugs and anti pruritus drugs were used within 24hours before the operation. * History of previous abnormal anaesthesia * Women during pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative analgesic failure | 8 a.m. at the first day after surgery. | Once patient experience at least one of the following situations: 1. Bad patients sleep quality 2. Require extra analgesic drug 3. Low satisfaction with pain control 4. Bolus times \> 1 per hour |
Countries
China
Outcome results
None listed