Smoking and Peptidoglycan Recognition Protein-1 and Initial Periodontal Therapy

The Effect of Smoking on Gingival Crevicular Fluid Peptidoglycan Recognition Protein-1 Level Following Initial Periodontal Therapy in Chronic Periodontitis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03915730

Enrollment

Registered

2019-04-16

Start date

2016-08-31

Completion date

2017-11-30

Last updated

2019-04-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Smoking, Cigarette

Keywords

Chronic periodontitis, gingival crevicular fluid, initial periodontal therapy, peptidoglycan recognition proteins, smoking

Brief summary

A total of 40 patients with CP (20 smokers (S+CP) and 20 nonsmokers (S-CP)) and 40 periodontally healthy subjects (20 smokers (S+PH) and 20 nonsmokers (S-PH)), comprising 80 subjects, were included in this study. Baseline GCF samples were obtained from all subjects and clinical periodontal measurements, including probing depth (PD), clinical attachment level (CAL), plaque index (PI), and gingival index (GI), were recorded. In patients who had received initial periodontal therapy, GCF samples were obtained and all clinical periodontal measurements were recorded again during the 6th-8th weeks. GCF PGRP-1 levels were analyzed by enzyme-linked immunosorbent assay.

Detailed description

Peptidoglycan recognition proteins (PGRPs) are one of the antimicrobial peptides that play a role in innate immunity and act against the bacterial cell wall. Smoking is the most important environmental risk factor for periodontitis. This study determined the effect of smoking on PGRP-1 levels in gingival crevicular fluid (GCF) in smokers and nonsmokers with chronic periodontitis (CP) following initial periodontal therapy.

Interventions

OTHERInitial periodontal therapy

Scaling and root planing and polishing with specific curettes were performed to patients with CP and oral hygiene education was provided to each patient.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Age

22 Years to 56 Years

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of severe chronic periodontitis * Clinical diagnosis of periodontal health

Exclusion criteria

* have any systemic disease, * to be alcohol consumer, * to receive any periodontal therapy in the past 6 months, * to take any drugs regularly * to be pregnant and/or lactate.

Design outcomes

Primary

Measure	Time frame	Description
Change in peptidoglycan recognition protein-1	Baseline and 3 months	Total amount of Peptidoglycan Recognition Protein-1 (µg) in gingival crevicular fluid

Secondary

Measure	Time frame	Description
Change in periodontal clinical parameter	Baseline and 3 months	Clinical attachment level (mm) (from cemento-enamel junction to the base of periodontal pocket)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026