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Diffusion Weighted MRI Accuracy in Cholesteatoma Localization

Diffusion Weighted MRI Accuracy in Cholesteatoma Localization

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03915392
Acronym
CHOLEMRI
Enrollment
30
Registered
2019-04-16
Start date
2018-07-01
Completion date
2019-07-31
Last updated
2019-04-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholesteatoma

Keywords

Diffusion weighted MRI, Cholesteatoma, Localization

Brief summary

Magnetic resonance imaging of the middle ear has an increasing place in the therapeutic strategy in otology and especially for cholesteatoma. It is currently performed for complicated cholesteatomas and as part of the follow-up of operated patients to detect a recurrence or a cholesteatoma residue (alternative of choice to second look surgery). Some people take CT and MRI fusion to improve the localization of cholesteatoma. Many studies have investigated the diagnostic capabilities of MRI but very few have demonstrate their reliability in location diagnosis. The aim of the study was to propose a topographic reading method of the MRI of the middle ear and to evaluate the performances in the localization of the cholesteatoma in order to adapt the surgical management

Interventions

None listed

Sponsors

University Hospital, Strasbourg, France
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Age: from 1 month and up * Sex: man / woman * Patient who had a tympanoplasty in closed technique, for the first surgical time of a cholesteatoma or for residual or recurrent cholesteatoma, performed by the same radiologist (Pr Anne Charpiot) with the following characteristics: * Code of the Common Classification of Medical Acts (CCAM) * Exeresis of cholesteatoma with tympanoplasty in closed technique and ossiculoplasty (CBFA002) * Exeresis of cholesteatoma with tympanoplasty in closed technique (CBFA006) * Exeresis of cholesteatoma confined to the tympanic cavity without antro-attic exploration (CBFA005) * Tympanoplasty in closed technique with posterior tympanotomy (CBMD001) * Secondary tympanoplasty in closed technique (CBMD002) * Diagnostic code of the International Classification of Diseases (ICD10) * Cholesteatoma of the middle ear (H71) * Diagnosis of macroscopic and / or pathological cholesteatoma. * Preoperative diagnosis of cholesteatoma on MRI of the middle ear performed in less than 6 months by the same radiologist (Pr Francis Veillon). * Subject (or the holders of parental authority in the case of minors) having agreed to the use of medical data for the purpose of this research. Cholesteatoma is a very common disease in the pediatric population, with important functional issues, whose treatment is surgical. That's why our study includes minor subjects. Criteria of non-inclusion * Refusal of the patient to participate in the study * Absence of data concerning the diagnosis and / or localization of cholesteatoma on the operative record * Subject under the protection of justice * Subject under guardianship or curatorship * Pregnancy (woman of childbearing age) * Breastfeeding

Design outcomes

Primary

MeasureTime frame
MRI imaging study to locate cholesteatoma.The period from January 1st, 2010 to Dcember 31, 2017 will be examined

Countries

France

Contacts

Primary ContactAnne CHARPIOT, MD, PhD
anne.charpiot@chru-strasbourg.fr33 3 88 12 76 49
Backup ContactAntoine MERANGER, MD
antoine.meranger@chru-strasbourg.fr33 3 88 12 76 49

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026