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Balancing of Patients Treated by Vitamin K Antagonists (VKAS) in General Medicine

Balancing of Patients Treated by Vitamin K Antagonists (VKAS) in General Medicine : Study ok Variables Influencing the Time Paid in the Therapeutic Target

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03914053
Acronym
VKA
Enrollment
3387
Registered
2019-04-12
Start date
2017-07-01
Completion date
2018-12-31
Last updated
2019-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thromboembolism

Brief summary

Despite the rise in prescriptions for direct oral anticoagulants,Vitamin K antagonists(VKA) remains the most prescribed treatment for treating and preventing long-term thromboembolic events. They remain the most important drugs of iatrogenic accidents despite the means deployed by the health authorities. The balance of the patients under VKA can be appreciated thanks to the time spent in the therapeutic zone or TTR which is correlated with the risk of occurrence of haemorrhagic or thrombotic events.

Detailed description

Despite the rise in prescriptions for direct oral anticoagulants, Vitamin K antagonists (VKA) remains the most prescribed treatment for treating and preventing long-term thromboembolic events. They remain the most important drugs of iatrogenic accidents despite the means deployed by the health authorities. The balance of the patients under VKA can be appreciated thanks to the time spent in the therapeutic zone or TTR which is correlated with the risk of occurrence of haemorrhagic or thrombotic events. The management of VKA in France seems hardly comparable to that of the neighboring countries in front of: * A TTR estimated at 60%. * Majority management of anticoagulant treatments by general practitioners. * The weak development of clinics anticoagulants. * The takeoff of direct oral anticoagulant prescriptions. * Preponderance of fluindione prescriptions among the various oral anticoagulants. It therefore seems interesting to study a cohort of French patients under VKA. Through the calculation of the TTR, the investigators will be able to draw a picture of the balance of the anticoagulant treatment and try to identify factors that can influence it.

Interventions

None listed

Sponsors

University Hospital, Montpellier
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Inclusion criteria

* Patient treated with VKA. * Realization of INR in one of the labs of the territory of LaboSud Oc biology between 1 September 2015 and 13 January 2016.

Exclusion criteria

* Less than 3 INR during the data collection period (TTR calculation not possible). * Time greater than 56 days between two INRs (calculation of the invalid TTR). * Interrupted treatment (calculation of invalid TTR). * Lack of information about the patient

Design outcomes

Primary

MeasureTime frameDescription
time spent in the therapeutic range (TTR)1 daycalculating their time spent in the therapeutic range (TTR).

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026