The Influence of Peripheral Nerve Blocks in Patients Undergoing Limb Orthopedic Surgery

Preoperative Peripheral Nerve Blocks Attenuate Intraoperative Surgical Stress and Postoperative Pain in Patients Undergoing Orthopedic Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03913650

Enrollment

Registered

2019-04-12

Start date

2017-05-15

Completion date

2018-12-31

Last updated

2020-02-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Postoperative, Change; Circulatory, Surgical Injury

Keywords

peripheral nerve block, IL-6, post-operative pain, limb surgery

Brief summary

To investigate pre-op peripheral nerve block in reducing peri-op IL-6 level and post-op pain

Detailed description

In orthopedic surgery, peripheral nerve block can be used as an anesthesia adjuvant prior to surgery. In this study, we hypothesized that peripheral nerve blocks may alleviate inflammatory response and reduce the analgesics requirement. Sixty patients undergoing limb orthopedic surgery will be enrolled. Peripheral nerve block was injected with 0.25% bupivacaine under ultrasound guidance. 30 patients (Study group) underwent surgery with nerve blocks and another 30 patients (Control group) underwent surgery with morphine. The anesthetic protocol was standardized for both groups by experienced anesthesiologists. Surgical stress was assessed by blood pressure fluctuation and proinflammatory cytokine. Pain intensity was measured by numeric rating scale (NRS) score for 24 hours

Interventions

PROCEDURE0.25% bupivacaine

nerve block procedure will be decided by patients' will for post-op pain

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* diagnosis of limb fracture * must receiving orthopedic surgery

Exclusion criteria

* With the comorbidity of chronic heart, lung, liver and renal disease, Chronic alcoholism, Allergy to bupivacaine

Design outcomes

Primary

Measure	Time frame	Description
peak pain intensity in the postoperative care unit	2 hours	pain score evaluated by pain score

Secondary

Measure	Time frame	Description
change of perioperative IL-6 level	up to 6 hours	blood samples assessed by ELISA

Other

Measure	Time frame	Description
changes of perioperative hemodynamic parameter	up to 3 hours	heart rate

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026