Benign Prostatic Hyperplasia
Conditions
Keywords
transurethral prostatectomy, copeptin, hyponatremia, risk prediction
Brief summary
Hyponatremic hypovolemia is a frequent complication of transurethral resection of the prostate gland (TURP). Copeptin has been established as is a surrogate marker of vasopressin and is measured useful for thea clinical assessment of various sodium and water disturbances. The aim of our the study was to assess the utility of serum concentration of copeptin (CPP) and brain natriuretic peptide (NT-proBNP) for the prediction of postoperative alterations of serum sodium concentration. Study population comprised 43 patients with benign prostatic hyperplasia (BPH) undergoing transurethral resection of the prostate gland. In a forward stepwise multiple regression only serum copeptin before the surgery and the duration of TURP significantly explained the variation of sodium concentration for 12 hours from the start of the surgery. Serum NT-proBNP before the surgery did not predict hyponatremia 12 hours after TURP.Conclusion Serum copeptin before TURP surgery but not NT-proBNP may be a clinically useful marker of a decrease of serum sodium after TURP surgery.
Detailed description
Introduction.Hyponatremic hypovolemia is a frequent complication of transurethral resection of the prostate gland (TURP). Copeptin has been established as is a surrogate marker of vasopressin and is measured useful for thea clinical assessment of various sodium and water disturbances. The aim of our the study was to assess the utility of serum concentration of copeptin (CPP) and brain natriuretic peptide (NT-proBNP) for the prediction of postoperative alterations of serum sodium concentration. Methods. Study population comprised 43 patients with benign prostatic hyperplasia (BPH) undergoing transurethral resection of the prostate gland (TURP) Serum sodium and copeptin (CPP) were measured before the procedure and 12 hours after its completion. and sSerum NT-proBNP was assessment at baseline. Total amount of fluids and sodium administered intravenously and to flush the bladder during TURP was calculated in each patient. Receiver operator characteristics (ROC) curve analysis was used to determine the value of of copeptin (CPP) and NT-proBNP for that could prediction of the decrease of serum sodium after TURP
Interventions
DIAGNOSTIC_TESTserum copeptin
routine surgical method using resectoscope inserted into the urinary bladder
Sponsors
Medical University of Lodz
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
\- glomerular filtration rate estimated from serum creatinine with CKD-EPI formula (eGFR) \>45 ml/min.
Exclusion criteria
* acute infection * heart failure (NYHA stage 3 or 4) * diabetes insipidus * nephrogenic diabetes insipidus * other sodium homeostasis abnormalities * impaired consciousness * psychogenic polydipsia * alcohol abuse.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change of serum sodium after surgery | change of serum sodium from baseline to 12 hours post surgery | predictive value of serum copeptin measured before surgery for serum sodium change after the surgery |
Countries
Poland
Outcome results
None listed