Sleep Disorder
Conditions
Brief summary
The purpose of this study is to determine the sleep patterns of subjects with or without sleep disturbances (insomnia, sleep apnea) and compare these findings with their previous FDG/PIB PET, structural MRI and brain blood flow scams performed during their participation in the Following studies 'Alzheimer's Disease Core Center (ADCC) Clinical Evaluation' (IRB: 2942), MRI Progression Markers of Cognitive Decline in the Elderly' (IRB:09-0586), or 'Imaging Neuro inflammation in Alzheimer's Disease with \[11C\] Arachidonic Acid (AA) and PET'(IRB: 10-00442).
Interventions
DIAGNOSTIC_TESTStructural 3T MRI
measures of global and hippocampal atrophy)
DIAGNOSTIC_TESTMRI Based Perfusion Imaging
brain blood flow
DIAGNOSTIC_TESTVR-CO2 MRI Scans
reduced vaso reactivity to carbon dioxide
Sponsors
NYU Langone Health
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
55 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* All subjects will have participated in prior CBH studies and have agreed to an FDG, PIB and MRI scans.
Exclusion criteria
* Diagnosis of sleep apnea and under treatment with a continuous positive airway pressure (CPAP) machine. * Active depressive episode during the evaluation with a Geriatric Depression Scale score \>7 and/or a Clinical Global Impression scale for depression score \>4. * Moderate Cognitive decline (GDS \>3). * Severe primary or secondary insomnia except insomnia due to SDB.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure of vasoreactivity to CO2 (VRCO2) | 1 Week | subjects will breath through a respiratory tube and CO2 will be meaured |
| Increase in cortical AB plaque burden | 1 Week | Measured by PIB PET |
| Decreased cerebral blood flow (CBF) | 1 Week | Measured by perfusion MRI |
Countries
United States
Outcome results
None listed