Cardiopulmonary Disease
Conditions
Brief summary
Researchers are trying to develop innovative strategies that target the early identification heart and lung imbalances in patients with cardiopulmonary diseases.
Interventions
OTHEREchocardiography
We hypothesize that non-invasive indices of RV (echocardiograph-derived strain and strain rate) and pulmonary (gas exchange-derived lung diffusion and surface area) function during light exercise will successfully identify and discern patients with known RV dysfunction (PAH/HFpEF with RV failure) from those with known pulmonary dysfunction (PAH/HFpEF with pulmonary fibrosis). Additionally, we hypothesize that our assessment techniques will identify subtle derangements in RV and pulmonary function in newly diagnosed PAH and HFpEF patients, and that this may guide early and targeted therapeutic intervention.
OTHERPulmonary Gas Exchange
We hypothesize that breathing hyperoxia will increase exercise capacity by reversing RV and pulmonary derangements, and that the mechanisms of action will be related to the underlying dysfunction (e.g., reducing PVR, increasing RV functional reserve, increasing gas diffusion).
Sponsors
Mayo Clinic
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy controls (no known cardiac or pulmonary disease); * PAH/HFpEF patients with known RV failure; * PAH/HFpEF patients with known pulmonary failure * Newly diagnosed PAH/HFpEF patients without any evidence of profound RV or pulmonary dysfunction.
Exclusion criteria
* Persons unable to perform light exercise * Persons pregnant or planning to be pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in stroke volume (SV) during exercise and hyperoxia | 2 years | Stroke volume will be measured with echocardiography at rest and during exercise while breathing room air and hyperoxia |
| Change in oxygen uptake (VO2) during exercise and hyperoxia | 2 years | Oxygen uptake will be measured via pulmonary gas exchange at rest and during exercise while breathing room air and hyperoxia |
| Change in ventilatory efficiency (VE/VCO2) during exercise and hyperoxia | 2 years | Ventilatory effciency will be measured via pulmonary gas exchange at rest and during exercise while breathing room air and hyperoxia |
Countries
United States
Outcome results
None listed