Thyroid Intra-Operative Injury
Conditions
Keywords
intraoperative neural monitoring
Brief summary
Objectives: The use of neuromuscular blocking agent may interfere with the function of intraoperative neuromonitoring (IONM) in thyroid surgery.
Detailed description
An enhanced neuromuscular-blockade (NMB) recovery protocol was investigated in a clinically applied during thyroid neural monitoring surgery. In as subsequent clinical application study, 60 patients who underwent thyroidectomy with IONM followed an enhanced NMB recovery protocol- rocuronium 0.6 mg/kg at anesthesia induction and sugammadex 2 mg/kg at operation start. Train-of-four (TOF) ratio was used for continuous quantitative monitoring of neuromuscular transmission.
Interventions
DRUGsugammadex
standard general anesthesia protocol with sugammadex
Sponsors
Kaohsiung Medical University Chung-Ho Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy
Exclusion criteria
* Patients with a history of significant cardiac, pulmonary, hepatic, or renal disease, body mass index \<18.5 or \>35, chronic drug or alcohol abuse
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sugammadex 2 mg/kg allows effective and rapid restoration of neuromuscular function suppressed by rocuronium | 1 month each case | Electromyography signal to assess the quality of neuromonitoring |
Countries
Taiwan
Outcome results
None listed