Periodontal Diseases
Conditions
Keywords
interleukin-18, gingival crevicular fluid, tumor necrosis factor alpha
Brief summary
This study aimed to evaluate the levels of interleukin 18 and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF) of children with type 1 diabetes mellitus and gingivitis.
Detailed description
Eighty eight children (44 with type 1 diabetes mellitus and 44 healty; age range 7-14 years) will be recruited for the study. The children will be classified into four subgroups based on their periodontal status; 1) Children with gingivitis and diabetes mellitus (MG, n=22); 2) Children with type 1 diabetes mellitus with healthy periodontium (MH, n=22); 3)Healthy children with gingivitis (HG, n=22); 4) Healthy children with healthy periodontium (HH, n=22). Probing pocket depth (PPD), gingival index (GI) and plaque index (PI) will be recorded. Interleukin-18 and TNF-α will be analyzed in GCF and saliva samples by ELISA.
Interventions
DIAGNOSTIC_TESTELISA
Enzim linked immunoabsorbant assay
Sponsors
Aydin Adnan Menderes University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
7 Years to 14 Years
Healthy volunteers
Yes
Inclusion criteria
* Children diagnosed as type 1 diabetes mellitus * Age between 7 and 14 years
Exclusion criteria
* Having another systemic problem except type 1 diabetes mellitus * Children carrying orthodontic appliances
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Interleukin-18 level | Baseline | IL-18 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tnf-alpha level | Baseline | Tnf-Alpha |
Countries
Turkey (Türkiye)
Outcome results
None listed