Dynamic Arterial Elastance During General Anesthesia Induction

Dynamic Arterial Elastance as Predictive Parameter of Hypotension During General Anesthesia Induction.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03910179

Enrollment

Registered

2019-04-10

Start date

2019-09-10

Completion date

2021-04-30

Last updated

2020-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Brief summary

This study evaluates if dynamic arterial elastance measured before general anesthesia induction can predict the occurrence of hypotension due to general anesthesia induction.

Detailed description

As general anesthetics may be responsible for vasodilation and cardiac depression, arterial hypotension after induction of general anesthesia is a common event and may contribute to an adverse outcome. Dynamic arterial elastance has been proposed as a functional parameter of arterial tone and studies showed that it was able to predict pressure response to fluid administration in fluid-responsive patients and the amount of mean arterial pressure riduction as a conseguence of noradrenaline dose reduction in critically ill patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients that will be undergone to general anesthesia for surgery * Patients that need mini-invasive cardiac output monitoring during surgery

Exclusion criteria

* Age \<18 yo * Pregnancy * Arrhythmia * Severe valvular diseases * Uncorrectable alterations of arterial signal

Design outcomes

Primary

Measure	Time frame	Description
Baseline value of Eadyn as predictor of hypotension occurrence due to general anesthesia induction	From baseline (before general anesthesia induction) up to 30 minutes.	Dynamic arterial elastance (Eadyn) will be recorded at baseline before induction of general anesthesia. Mean arterial pressure (MAP) will be recorded at baseline and continuously until tracheal intubation. The lowest value of MAP will be considered to define hypotension occurrence.

Secondary

Measure	Time frame	Description
Correlation between Eadyn and severity of hypotension due to anesthesia induction	From baseline (before general anesthesia induction) up to 30 minutes.	To evaluate the correlation between the baseline value of Eadyn and the severity of hypotension when it will occur after induction of general anesthesia

Countries

Italy

Outcome results