Endometrial Fluid
Conditions
Brief summary
This study is designed to collect information about the characteristics of endometrial fluid at day 2 and day 4 post-ovulation in normal fertile women.
Detailed description
Implantation rates have stabilised around 35% in IVF and a current key rate limiting step is achieving successful implantation of the embryo. 1/3 of implantation failures are estimated to be caused by a problem with the receptivity of the endometrium. In recent years, several measurable parameters have been reported to assess endometrial receptivity. However, one parameter remains undescribed, the endometrial fluid viscosity. It is generally believed that the viscosity change post ovulation is influenced by the luteal phase endocrine milieu, and it is possible that the viscosity of the endometrial fluid has an impact on implantation.
Interventions
None listed
Sponsors
Anecova SA
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
No minimum to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Age: ≤ 35 years * Women eligible and qualified for egg donation at IVIRMA Bilbao * Proven fertile (having given birth to at least one spontaneously conceived normal child) * Signed written consent including sharing of anonymized data
Exclusion criteria
* Contraindications for egg donation according to IVIRMA Bilbao guidelines
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Viscosity of endometrial fluid at D2 and D4 post ovulation of the normal cycle, respectively | 4 days |
Secondary
| Measure | Time frame |
|---|---|
| Plasma progesterone level | 4 days |
| Plasma estradiol (E2) level | 4 days |
| Endometrial thickness as measured by ultrasound | 4 days |
Countries
Spain
Outcome results
None listed