Assessing Best Medical Treatment Patterns of Patients With Symptomatic Peripheral Arterial Occlusive Disease in Germany

Conditions

Critical Limb Ischemia, Intermittent Claudication, Peripheral Artery Disease

Brief summary

This proposed study will be conducted to support real-world-evidence on the extent of best medical treatment for secondary prevention of patients with symptomatic peripheral arterial occlusive disease (PAOD) for prevention of worsening limb symptoms or of major adverse cardiovascular events. The overall objective of this study is to gain a better understanding of patient characteristics, treatment patterns and outcomes in PAOD patients. For this purpose the investigators will analyze a patient population hospitalized either with intermittent claudication (IC) or chronic limb-threatening ischaemia (CLTI) while taking prior PAOD-related diagnoses in the outpatient setting into account. In detail, we study differentials according to age, calendar time, sex, disease severity and hospital procedure. Data were extracted from available German health insurance claims.

Frederik Peters, Jenny Kuchenbecker, Laura Acar, Ursula Marschall, Helmut L’Hoest et al. (8 authors)

Journal of Clinical Medicine2022-09-1611 citations

10.3390/jcm11185455

Editor's Choice - Optimal Pharmacological Treatment of Symptomatic Peripheral Arterial Occlusive Disease and Evidence of Female Patient Disadvantage: An Analysis of Health Insurance Claims Data.

Peters F, Kreutzburg T, Rieß HC, Heidemann F, Marschall U, L'Hoest H, Debus ES, Sedrakyan A, Behrendt CA.

2020-07-1230 citations

10.1016/j.ejvs.2020.05.001

A retrospective cohort study on the provision and outcomes of pharmacological therapy after revascularisation for peripheral arterial occlusive disease: a study protocol

Frederik Peters, Thea Kreutzburg, Jenny Kuchenbecker, Sebastian Debus, Ursula Marschall et al. (7 authors)

BMJ Surgery Interventions & Health Technologies2020-01-0110 citations

10.1136/bmjsit-2019-000020

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

1. First clinical diagnosis of symptomatic peripheral arterial occlusive disease (according to Fontaine classification, stages II, III and IV) after at least 5 years without such clinical diagnosis 2. At least 18 years of age

Exclusion criteria

3. Incomplete information on sex, age, date of hospital discharge 4. Less than 5 years of insurance membership before index stay

Design outcomes

Primary

Measure	Time frame	Description
Number of participants receiving best-medical-treatment	at 12 months after discharge	Prevalence of the outpatient prescription of best medical treatment defined as picking up a medication at a pharmacy for a lipid-lowering, an antithrombotic, and an antihypertensive drug agent, within 12 months after index discharge for POAD according to information provided in health insurance claims data

Secondary

Measure	Time frame	Description
Number of participants deceased	at 5 years after discharge	Rate of all-cause mortality after index discharge for POAD according to information provided in health insurance claims
Lower extremity amputation	at 5 years after discharge	Rate of lower extremity amputation after index discharge for POAD according to information provided in health insurance claims
Number of participants with a myocardial infarction	at 5 years after discharge	Rate of myocardial infarction after index discharge for POAD according to information provided in health insurance claims
Number of participants with a stroke or transient ischaemic attack	at 5 years after discharge	Rate of stroke or TIA after index discharge for POAD according to information provided in health insurance claims
Number of participants with a major bleeding	at 5 years after discharge	Rate of major bleeding provided in health insurance claims

Outcome results